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Cx26 heterozygous mutations: role in hyperacusis and vulnerability to noise.

作者信息

Tawk Karen, Abouzari Mehdi

机构信息

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.

出版信息

Signal Transduct Target Ther. 2023 Jul 10;8(1):264. doi: 10.1038/s41392-023-01525-1.

DOI:10.1038/s41392-023-01525-1
PMID:37423920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10330177/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c722/10330177/5833409a00e1/41392_2023_1525_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c722/10330177/5833409a00e1/41392_2023_1525_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c722/10330177/5833409a00e1/41392_2023_1525_Fig1_HTML.jpg

相似文献

1
Cx26 heterozygous mutations: role in hyperacusis and vulnerability to noise.Cx26杂合突变：在听觉过敏及噪声易感性中的作用
Signal Transduct Target Ther. 2023 Jul 10;8(1):264. doi: 10.1038/s41392-023-01525-1.
2
Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise.Cx26 杂合突变导致类似听觉过敏的听力过度敏感，并增加对噪声的易感性。
Sci Adv. 2023 Feb 10;9(6):eadf4144. doi: 10.1126/sciadv.adf4144. Epub 2023 Feb 8.
3
A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall.一种由双基因 Cx26（GJB2）和 Cx30（GJB6）突变引起的耳聋机制：通过损害耳蜗外侧壁中的异质缝隙连接功能来降低内耳电位。
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Effects of noise exposure on development of tinnitus and hyperacusis: Prevalence rates 12 months after exposure in middle-aged rats.噪声暴露对耳鸣和听觉过敏发展的影响：中年大鼠暴露后12个月的患病率
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本文引用的文献

1
Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise.Cx26 杂合突变导致类似听觉过敏的听力过度敏感，并增加对噪声的易感性。
Sci Adv. 2023 Feb 10;9(6):eadf4144. doi: 10.1126/sciadv.adf4144. Epub 2023 Feb 8.
2
LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB).低密度脂蛋白受体相关蛋白 1（LRP1），血迷路屏障（BLB）开放的新靶点。
Signal Transduct Target Ther. 2022 Jun 10;7(1):175. doi: 10.1038/s41392-022-00995-z.
3
Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss - A Common Hereditary Deafness.
连接蛋白突变导致听力损失的细胞机制与耳聋机制——一种常见的遗传性耳聋
Front Cell Neurosci. 2015 May 29;9:202. doi: 10.3389/fncel.2015.00202. eCollection 2015.
4
Hearing loss associated with an unusual mutation combination in the gap junction beta 2 (GJB2) gene in a Chinese family.一个中国家庭中与缝隙连接蛋白β2（GJB2）基因异常突变组合相关的听力损失
Int J Pediatr Otorhinolaryngol. 2014 Apr;78(4):599-603. doi: 10.1016/j.ijporl.2014.01.008. Epub 2014 Jan 17.
5
A novel connexin 26 compound heterozygous mutation results in deafness.一种新的连接蛋白26复合杂合突变导致耳聋。
Laryngoscope. 2002 Jul;112(7 Pt 1):1159-62. doi: 10.1097/00005537-200207000-00003.