Ou Yingwei, Xu Yifan, Tan Zhaowang, Pang Lingxiao, Li Shengqin, Li Qian, Cai Wenwei, Nan Yong, Tu Jianfeng
Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, Zhejiang, PR China.
Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu, 230030, Anhui Province, PR China.
Thromb J. 2023 Jul 10;21(1):74. doi: 10.1186/s12959-023-00507-1.
With its low morbidity and high mortality rates, thrombotic thrombocytopenic purpura (TTP) has imposed a critical physical and economic burden on both society and individuals. Thrombocytopenia commonly occurs in severe liver failure, and a variety of hepatitis viruses are known to induce immune thrombocytopenic purpura. However, TTP is extremely rare in hepatitis E virus infection. We hereby report a case of a 53-year-old male who present with TTP caused by severe hepatitis E, and the patients achieved successful recovery after treatment. Therefore, we propose considering AMAMTS13 testing as an essential and beneficial approach for accurately diagnosing and treating patients with severe hepatitis or infection with notable platelet decline.
血栓性血小板减少性紫癜（TTP）发病率低但死亡率高，给社会和个人都带来了严重的身体和经济负担。血小板减少症常见于严重肝功能衰竭，已知多种肝炎病毒可诱发免疫性血小板减少性紫癜。然而，戊型肝炎病毒感染中TTP极为罕见。我们在此报告一例53岁男性患者，其因严重戊型肝炎引发TTP，经治疗后成功康复。因此，我们建议将ADAMTS13检测作为准确诊断和治疗重症肝炎或血小板显著减少的感染患者的重要且有益的方法。
