Ophthalmology Department, Gaziantep University Hospital, Gaziantep, Turkey.
Ophthalmology Department, Kocaeli University Hospital, Kocaeli, Turkey.
Eur J Ophthalmol. 2024 Jan;34(1):175-180. doi: 10.1177/11206721231187427. Epub 2023 Jul 9.
To investigate the relationship between serum iron status indicators (ferritin) levels and POAG.
The files of all glaucoma patients who applied to the ophthalmology clinic between January 2018 and January 2022 were reviewed retrospectively. Laboratory data from fasting blood tests, internal medicine outpatient clinic reports, and extensive ophthalmologic examination data, including fundus photographs showing the optic disc, were collected from the files. A control group was formed from individuals with adequate general and eye health, age- and gender-matched individuals who had undergone examination in the ophthalmology clinic within the same date range. Serum iron status indicators and some laboratory data of POAG patients and healthy controls were compared.
Of our participants, consisting of 65 patients with POAG and 72 healthy controls, 84 (61.32%) were female and 53 (38.68%) were male. It was observed that serum ferritin level was significantly higher in POAG patients compared to healthy controls, and the total iron binding capacity was significantly lower (respectively (p = 0.022), (p = 0.002). In logistic regression analysis, it was found that the risk of POAG increased in cases with high serum ferritin levels (OR = 0.982; p = 0.012). In addition, the risk of POAG was found to increase in cases where MCV was lower (OR = 1.121; p = 0.039).
This study shows that higher serum ferritin levels are associated with a higher risk of POAG.
探讨血清铁状态指标（铁蛋白）水平与 POAG 的关系。
回顾性分析 2018 年 1 月至 2022 年 1 月期间在眼科诊所就诊的所有青光眼患者的病历。从病历中收集空腹血检查、内科门诊报告的实验室数据以及广泛的眼科检查数据，包括显示视盘的眼底照片。从同一日期范围内在眼科诊所接受检查的一般和眼部健康状况良好的个体中组建对照组。比较 POAG 患者和健康对照者的血清铁状态指标和一些实验室数据。
在我们的参与者中，包括 65 名 POAG 患者和 72 名健康对照者，84 名（61.32%）为女性，53 名（38.68%）为男性。观察到 POAG 患者的血清铁蛋白水平明显高于健康对照组，总铁结合力明显降低（分别为（p = 0.022），（p = 0.002）。在逻辑回归分析中，发现血清铁蛋白水平升高会增加 POAG 的发病风险（OR = 0.982；p = 0.012）。此外，还发现 MCV 降低会增加 POAG 的发病风险（OR = 1.121；p = 0.039）。
本研究表明，较高的血清铁蛋白水平与 POAG 的发病风险增加相关。
