Department of Surgical Pathology, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Radiology and Neurology, Division of Neuroradiology and ENT, Thomas Jefferson University, Philadelphia, PA, USA.
Int J Surg Pathol. 2024 May;32(3):601-606. doi: 10.1177/10668969231185073. Epub 2023 Jul 10.
Oxalosis refers to the accumulation of calcium oxalate crystals in various organs and tissues, most commonly due to infection involving the lung or sinonasal tract. Both invasive and noninvasive forms of fungal rhinosinusitis can be associated with calcium oxalate crystal deposition. Here, we report a unique case of sinonasal oxalosis presenting as a destructive lesion in the absence of invasive fungal disease. Due to the clinical and pathologic significance of calcium oxalate crystals as seen in this patient, specimens from the sinonasal tract should be evaluated for the presence of these crystals, which may be a surrogate marker for fungal infection and may also independently cause tissue destruction.
草酸钙沉积症是指钙草酸晶体在各种器官和组织中的积累，最常见于肺部或鼻旁窦感染。侵袭性和非侵袭性真菌性鼻旁窦炎均可与钙草酸晶体沉积有关。在此，我们报告了一例独特的鼻旁窦草酸钙沉积症病例，其表现为破坏性病变，而无侵袭性真菌病。由于该患者的钙草酸晶体具有临床和病理意义，因此应对鼻旁窦标本进行这些晶体的评估，这些晶体可能是真菌感染的替代标志物，也可能独立引起组织破坏。
