Zandman-Goddard G, Matzner Y, Konijn A M, Hershko C
Cancer. 1986 Sep 15;58(6):1346-9. doi: 10.1002/1097-0142(19860915)58:6<1346::aid-cncr2820580627>3.0.co;2-w.
Cerebrospinal fluid (CSF) ferritin was measured in patients with benign inflammatory and noninflammatory neurologic disorders and in patients with malignant disease with and without documented central nervous system (CNS) involvement. CSF ferritin levels were increased in the majority of patients with inflammatory neurologic disease and in patients with malignant involvement of the CNS. In contrast, in patients with noninflammatory neurologic disorders and in malignant disease without CNS involvement, CSF ferritin levels were normal. These findings indicate that although the specificity of CSF ferritin measurement is limited, it is a highly sensitive test that may be useful in the initial evaluation of patients with malignant CNS involvement, and in assessing their response to therapy.
对患有良性炎症性和非炎症性神经系统疾病的患者，以及患有恶性疾病且有或无中枢神经系统（CNS）受累记录的患者进行了脑脊液（CSF）铁蛋白检测。大多数炎症性神经系统疾病患者以及CNS受累的恶性疾病患者的CSF铁蛋白水平升高。相比之下，非炎症性神经系统疾病患者以及无CNS受累的恶性疾病患者的CSF铁蛋白水平正常。这些发现表明，虽然CSF铁蛋白检测的特异性有限，但它是一项高度敏感的检测，可能有助于对CNS受累的恶性疾病患者进行初步评估，以及评估他们对治疗的反应。
