Sijapati Nikita, Fong Suy Sen Hung, Ansari Omar, Misra Subhasis, Mercado Edgar A, Myers My, Narasimha Vijay
HCA Florida St. Petersburg Hospital, St. Petersburg, FL.
HCA Florida Brandon Hospital, Brandon, FL.
HCA Healthc J Med. 2023 Feb 28;4(1):43-49. doi: 10.36518/2689-0216.1214. eCollection 2023.
Calciphylaxis is a rare disorder that involves the formation of cutaneous, subcutaneous, and vascular calcifications. Although it is predominantly seen in patients with end-stage renal disease (ESRD), it has also been reported in patients without chronic kidney disease. The presence of multiple risk factors, a poorly understood mechanism, high mortality, and the lack of standardized treatment make calciphylaxis an important subject.
We describe the clinical presentation, disease course, and management of 3 patients with calciphylaxis and also provide a literature review. In all 3 patients, the diagnosis was confirmed histologically, and the management involved the continuation of renal replacement therapy, pain medication, wound debridement, and intravenous (IV) sodium thiosulphate.
Calciphylaxis should be suspected in ESRD patients presenting with painful areas of cutaneous induration, and the early recognition of these findings allows for prompt diagnosis and management.
钙化防御是一种罕见的疾病，涉及皮肤、皮下和血管钙化的形成。虽然它主要见于终末期肾病（ESRD）患者，但也有报道称在无慢性肾病的患者中出现。多种危险因素的存在、机制尚不清楚、高死亡率以及缺乏标准化治疗使得钙化防御成为一个重要课题。
我们描述了3例钙化防御患者的临床表现、病程及治疗，并进行了文献综述。所有3例患者均经组织学确诊，治疗包括继续肾脏替代治疗、止痛药物、伤口清创以及静脉注射硫代硫酸钠。
对于出现皮肤硬结疼痛区域的ESRD患者，应怀疑钙化防御，早期识别这些表现有助于及时诊断和治疗。
