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脂质多态性

Lipid polymorphism.

作者信息

Tilcock C P

出版信息

Chem Phys Lipids. 1986 Jun-Jul;40(2-4):109-25. doi: 10.1016/0009-3084(86)90066-6.

DOI:10.1016/0009-3084(86)90066-6
PMID:3742669
Abstract

In this review the polymorphic phase behaviour of several of the major classes of lipids found in biological membranes, both in isolation and also in mixtures, is briefly described. Emphasis is given to the ability of many membrane lipids to adopt non-lamellar phases in response to a variety of factors such as temperature, the presence of divalent cations or changes in pH. The phase behaviour of mixed lipid systems and factors which can modulate the phase preferences of such systems are considered in some detail particularly with regard to the effect of cholesterol upon lipid polymorphism.

摘要

在本综述中,简要描述了生物膜中几种主要脂质类别的多晶型相行为,包括单独的脂质以及脂质混合物的相行为。重点介绍了许多膜脂响应多种因素(如温度、二价阳离子的存在或pH值变化)而呈现非层状相的能力。特别详细地考虑了混合脂质体系的相行为以及可调节此类体系相偏好的因素,尤其是胆固醇对脂质多态性的影响。

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