El Sayed Razan, Shankar Karan Michael, Mankame Atharwa Rajan, Cox Charles S
Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Center for Translational Injury Research, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Transl Pediatr. 2023 Jun 30;12(6):1239-1257. doi: 10.21037/tp-23-92. Epub 2023 Jun 9.
Stem cell therapy is a regenerative medicine modality that has the potential to decrease morbidity and mortality by promoting tissue regeneration or modulating the inflammatory response. An increase in the number of clinical trials investigating the efficacy and safety of stem cell therapy in pediatric diseases has led to advancements in this field. Currently, multiple sources and types of stem cells have been utilized in the treatment of pediatric diseases. This review aims to inform researchers and clinicians about preclinical and clinical stem cell therapy trials in pediatric patients. We discuss the different types of stem cells and the wide spectrum of stem cell therapy trials for pediatric diseases, with an emphasis on the outcomes and advancements in the field.
PubMed and clinicaltrials.gov databases were searched on October 28, 2022 using the following Medical Subject Headings (MeSH) terms "stem cell" or "stem cell therapy" with an age filter <18 years. Our search was limited to publications published between 2000 and 2022.
Diverse sources of stem cells have different properties and mechanisms of action, which allow tailored application of stem cells according to the pathophysiology of the disease. Advancements in stem cell therapies for pediatric diseases have led to improvements in clinical outcomes in some pediatric diseases or in quality of life, such therapies represent a potential alternative to the current treatment modalities.
Stem cell therapy in pediatric diseases has shown promising results and outcomes. However, further studies focusing on the implementation and optimal treatment timeframe are needed. An increase in preclinical and clinical trials of stem cell therapy targeting pediatric patients is required to advance our therapeutic applications.
干细胞疗法是一种再生医学模式，有潜力通过促进组织再生或调节炎症反应来降低发病率和死亡率。越来越多关于干细胞疗法在儿科疾病中的疗效和安全性的临床试验推动了该领域的发展。目前，多种来源和类型的干细胞已被用于治疗儿科疾病。本综述旨在向研究人员和临床医生介绍儿科患者的临床前和临床干细胞疗法试验。我们讨论了不同类型的干细胞以及针对儿科疾病的广泛的干细胞疗法试验，重点关注该领域的成果和进展。
于2022年10月28日在PubMed和clinicaltrials.gov数据库中进行检索，使用以下医学主题词（MeSH）“干细胞”或“干细胞疗法”，并设置年龄过滤器<18岁。我们的检索限于2000年至2022年发表的文献。
不同来源的干细胞具有不同的特性和作用机制，这使得可以根据疾病的病理生理学定制干细胞的应用。儿科疾病干细胞疗法的进展已使一些儿科疾病的临床结局或生活质量得到改善，此类疗法是当前治疗方式的一种潜在替代方案。
儿科疾病的干细胞疗法已显示出有前景的结果。然而，需要进一步开展侧重于实施和最佳治疗时间框架的研究。需要增加针对儿科患者的干细胞疗法的临床前和临床试验，以推进我们的治疗应用。
