Takeuchi Daisuke, Ishida Mitsuaki, Yasuda Emi, Ueda Koichi, Hirose Yoshinobu
Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan.
Department of Plastic and Reconstructive Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan.
Oncol Lett. 2023 Jun 21;26(2):337. doi: 10.3892/ol.2023.13923. eCollection 2023 Aug.
Sebaceous carcinoma (SC) is a rare carcinoma classified as ocular or extraocular. Ocular SC is believed to arise from the meibomian glands or the glands of Zeis. However, the origin of extraocular SC is controversial because there is no evidence of carcinoma arising from pre-existing sebaceous glands. Several hypotheses about the origin of extraocular SC have been proposed, including one suggesting an origin from intraepidermal neoplastic cells. Although extraocular SCs have been shown to occasionally comprise intraepidermal neoplastic cells, no study has investigated whether intraepidermal neoplastic cells possess sebaceous differentiation. The present study analyzed the clinicopathological features of ocular and extraocular SC, with an emphasis on the presence of (intraepithelial) lesions. It retrospectively reviewed the clinicopathological features of eight patients with ocular and three patients with extraocular SC (eight women and three men; median age, 72 years), respectively. (intraepithelial) lesions were observed in four of the eight ocular SC cases and one of the three extraocular SC cases and an apocrine component was noted in one patient with ocular SC (seboapocrine carcinoma). In addition, immunohistochemical analyses showed that the androgen receptor (AR) was expressed in all ocular SCs and two of the three extraocular SC cases. Adipophilin expression was observed in all ocular and extraocular SC. lesions of extraocular SC showed positive immunoreactivity for both AR and adipophilin. The present study is the first to demonstrate sebaceous differentiation in lesions of extraocular SC. The possible origin of extraocular SC is speculated to be the progenitor cells present in the sebaceous duct or interfollicular epidermis. The results of the present study and reported cases of SC indicate that extraocular SC also arises from intraepidermal neoplastic cells.
皮脂腺癌（SC）是一种罕见的癌症，分为眼内型和眼外型。眼内型皮脂腺癌被认为起源于睑板腺或蔡司腺。然而，眼外型皮脂腺癌的起源存在争议，因为没有证据表明其癌起源于先前存在的皮脂腺。关于眼外型皮脂腺癌的起源已经提出了几种假说，其中一种认为起源于表皮内肿瘤细胞。尽管已经证明眼外型皮脂腺癌偶尔会包含表皮内肿瘤细胞，但尚无研究调查表皮内肿瘤细胞是否具有皮脂腺分化。本研究分析了眼内型和眼外型皮脂腺癌的临床病理特征，重点关注（上皮内）病变的存在情况。它分别回顾性分析了8例眼内型皮脂腺癌患者和3例眼外型皮脂腺癌患者（8名女性和3名男性；中位年龄72岁）的临床病理特征。8例眼内型皮脂腺癌病例中有4例观察到（上皮内）病变，3例眼外型皮脂腺癌病例中有1例观察到（上皮内）病变，1例眼内型皮脂腺癌患者（皮脂腺大汗腺癌）中发现了顶泌汗腺成分。此外，免疫组织化学分析显示，雄激素受体（AR）在所有眼内型皮脂腺癌以及3例眼外型皮脂腺癌中的2例中表达。所有眼内型和眼外型皮脂腺癌均观察到脂联素表达。眼外型皮脂腺癌的（上皮内）病变对AR和脂联素均显示阳性免疫反应。本研究首次证明眼外型皮脂腺癌的（上皮内）病变具有皮脂腺分化。推测眼外型皮脂腺癌的可能起源是皮脂腺导管或毛囊间表皮中存在的祖细胞。本研究结果及报道的皮脂腺癌病例表明，眼外型皮脂腺癌也起源于表皮内肿瘤细胞。
