Mindich B P, Guarino T, Goldman M E
Circulation. 1986 Sep;74(3 Pt 2):I130-5.
With the advent of reliable prosthetic valves, the number of aortic valvuloplastic procedures performed in adults has decreased significantly. This is in contradistinction to patients with congenital aortic stenosis, in whom aortic valvuloplasty remains the primary approach. Although only a 25% to 50% incidence of long-term clinical improvement has been reported after aortic valvuloplasty for acquired aortic stenosis, long-term success in adults can be predicted only if a valve area of greater than 1.0 cm2 is obtained, and if there is only minimal residual aortic insufficiency. Due to potential prosthetic valve-related complications aortic valvuloplasty was performed in 23 patients (14 women; nine men) with a mean age of 75 years (range 59 to 94). All patients had small aortic roots (20 less than or equal to 19 mm, 3 less than or equal to 21 mm) and a contraindication to anticoagulation. Baseline and postprocedure intraoperative two-dimensional contrast echocardiography was used to image leaflet mobility and the degree of aortic insufficiency. Cardiac outputs and pressure gradients were also recorded to calculate valve area before and after cardiopulmonary bypass. The postrepair gradient (mean 9 +/- 1.4 mm Hg) was significantly less (p = 0) than the prerepair gradient (mean 54 +/- 6.3 mm Hg). The postrepair valve area (mean 1.56 +/- 0.05 cm2) was significantly greater (p = 0) than the prerepair valve area (mean 0.55 +/- 0.05 cm2). Two patients required late reoperation: one for late bacterial endocarditis and one, whose valve area after valvuloplasty increased from 0.71 to only 0.91 cm2, for "restenosis."(ABSTRACT TRUNCATED AT 250 WORDS)
随着可靠的人工瓣膜的出现,成人主动脉瓣成形术的实施数量显著减少。这与先天性主动脉瓣狭窄患者形成对比,在这类患者中,主动脉瓣成形术仍是主要的治疗方法。尽管对于后天性主动脉瓣狭窄,主动脉瓣成形术后长期临床改善的发生率仅为25%至50%,但对于成人患者,只有当获得大于1.0平方厘米的瓣口面积且仅有轻微残余主动脉瓣关闭不全时,才能预测长期成功。由于人工瓣膜相关的潜在并发症,对23例患者(14例女性;9例男性)实施了主动脉瓣成形术,平均年龄75岁(范围59至94岁)。所有患者的主动脉根部较小(20例≤19毫米,3例≤21毫米)且有抗凝禁忌证。使用基线和术后术中二维对比超声心动图来成像瓣叶活动度和主动脉瓣关闭不全的程度。还记录心输出量和压力阶差,以计算体外循环前后的瓣口面积。修复后的压力阶差(平均9±1.4毫米汞柱)显著低于修复前的压力阶差(平均54±6.3毫米汞柱)(p = 0)。修复后的瓣口面积(平均1.56±0.05平方厘米)显著大于修复前的瓣口面积(平均0.55±0.05平方厘米)(p = 0)。两名患者需要后期再次手术:一名因晚期细菌性心内膜炎,另一名因“再狭窄”,其瓣膜成形术后瓣口面积从0.71平方厘米仅增加到0.91平方厘米。(摘要截短于250字)