Department of Family Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, 55100, Turkey.
Department of Gastroentrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Int J Colorectal Dis. 2023 Jul 10;38(1):188. doi: 10.1007/s00384-023-04468-9.
We investigated the relationship between expirium air carbon monoxide (E-CO) levels and disease severity in patients with ulcerative colitis (UC) and Crohn's disease (CD).
After their first follow-ups, the E-CO levels of 162 patients with UC and 100 with CD were measured for four consecutive weeks. Blood samples were collected from all the patients, and their clinical severity was determined 1 month after their initial presentation. The clinical severity of CD was determined using the Harvey Bradshaw index (HBI), while the patients with UC completed the SEO clinical activity index (SEOI). The relationships between the disease severity and the means of these four E-CO readings were then compared.
The mean age of the participants was 42.28 ± 14.9 years, and 158 (60.3%) were men. In addition, 27.2% of the UC group and 44% of the CD group were smokers. The mean SEOI score was 145.7 ± 42.0 (min = 90, max = 227), and the mean HBI score was 5.75 ± 3.3 (min = 1, max = 15). Increased CO ppm (OR = -9.047 to 7.654 95% CI) and the number of cigarettes smoked per day (OR = -0.161 to 1.157 95% CI) emerged as independent risk factors for lower SEO scores in the linear regression models (p < 0.001), while the number of cigarettes smoked per day (OR = 0.271 to 1.182% 95 CI) was a risk factor for higher HBI scores (p = 0.022).
UC severity decreased with higher E-CO levels and the mean number of cigarettes smoked, while CD severity increased in line with the mean number of cigarettes smoked.
我们研究了溃疡性结肠炎（UC）和克罗恩病（CD）患者呼气一氧化碳（E-CO）水平与疾病严重程度之间的关系。
在首次随访后，连续四周测量了 162 例 UC 患者和 100 例 CD 患者的 E-CO 水平。采集所有患者的血样，并在初次就诊后 1 个月确定其临床严重程度。CD 的临床严重程度采用 Harvey Bradshaw 指数（HBI）评估，UC 患者采用 SEO 临床活动指数（SEOI）评估。然后比较疾病严重程度与这四个 E-CO 读数平均值之间的关系。
参与者的平均年龄为 42.28±14.9 岁，158 名（60.3%）为男性。此外，UC 组 27.2%和 CD 组 44%的患者吸烟。SEOI 评分的平均值为 145.7±42.0（最小值=90，最大值=227），HBI 评分的平均值为 5.75±3.3（最小值=1，最大值=15）。线性回归模型显示，CO ppm 增加（OR=-9.047 至 7.654 95%CI）和每天吸烟量（OR=-0.161 至 1.157 95%CI）是 SEO 评分降低的独立危险因素（p<0.001），而每天吸烟量（OR=0.271 至 1.182%95 CI）是 HBI 评分升高的危险因素（p=0.022）。
UC 严重程度随 E-CO 水平和平均吸烟量的升高而降低，而 CD 严重程度随平均吸烟量的增加而升高。
