褐色眼皮肤白化病的分离分析
Segregation analysis of brown oculocutaneous albinism.
作者信息
King R A, Rich S S
出版信息
Clin Genet. 1986 Jun;29(6):496-501. doi: 10.1111/j.1399-0004.1986.tb00550.x.
Abstract
The segregation of brown (type IV) oculocutaneous albinism was analyzed in 18 Nigerian families. Analysis using the POINTER program showed that this type of oculocutaneous albinism was inherited in an autosomal recessive pattern, with an estimated gene frequency of 0.025 +/- 0.007 in this population. The enzyme defect responsible for brown oculocutaneous albinism is unknown.
摘要
对18个尼日利亚家庭的棕色（IV型）眼皮肤白化病的遗传情况进行了分析。使用POINTER程序分析表明，这种眼皮肤白化病以常染色体隐性模式遗传，在该人群中估计基因频率为0.025±0.007。导致棕色眼皮肤白化病的酶缺陷尚不清楚。
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