Kolb H, Oschilewski M, Schwab E, Greulich B, Roos P, Kiesel U
Diabetes Res. 1986 May;3(4):183-6.
The effect of immunomodulatory lectins on diabetes development following low-dose streptozotocin treatment in inbred mice was studied. All lectins administered had been shown previously to suppress immune reactivity. Among plant lectins concanavalin A but not Lens culinaris or wheat germ agglutinin partially suppressed hyperglycaemia following low-dose streptozotocin. A similar inhibitory effect was found for the staphylococcal enterotoxin B. Finally, administration of an immunomodulatory lectin from vertebrates, electrolectin, also had a beneficial effect on the course of the disease. These findings indicate that some lectins have a suppressive effect on Type 1 diabetes in an animal model.
研究了免疫调节凝集素对近交系小鼠低剂量链脲佐菌素治疗后糖尿病发展的影响。先前已证明所有施用的凝集素均能抑制免疫反应性。在植物凝集素中，伴刀豆球蛋白A可部分抑制低剂量链脲佐菌素后的高血糖症，而菜豆凝集素或麦胚凝集素则无此作用。葡萄球菌肠毒素B也有类似的抑制作用。最后，施用来自脊椎动物的免疫调节凝集素——电凝集素，对疾病进程也有有益影响。这些发现表明，在动物模型中，某些凝集素对1型糖尿病有抑制作用。
