Whitmore H L, Hurtgen J P, Mather E C, Seguin B E
J Am Vet Med Assoc. 1979 May 15;174(10):1113-5.
Two hundred twenty-five dairy cows with ovarian cysts were treated with 100 microgram of gonadotropin-releasing hormone (GnRH). Cows failing to recover were retreated with a second or third dose of GnRH. Clinical recovery following 1st, 2nd, and 3rd treatments was 76% (170/225), 78% (43/55), and 66% (8/12), respectively. Of the 221 cows that recovered, 184 eventually became pregnant. The remaining 41 cows were culled primarily as problem breeders. First-service conception rate was 49%. More ovarian cysts were detected in herds examined at 2-week intervals than in herds examined at 4-week intervals. The increased diagnosis of ovarian cysts may have been related to detection of cysts prior to spontaneous recovery that occurs in some cases. Clinical recovery from ovarian cysts was lower in herds examined at 2-week intervals following treatment, compared with those examined at 4-week intervals. The GnRH-induced luteinization of ovarian cysts and response to treatment was more difficult to judge at 2 weeks than at 4 weeks.
225头患有卵巢囊肿的奶牛接受了100微克促性腺激素释放激素（GnRH）治疗。未恢复的奶牛接受了第二剂或第三剂GnRH治疗。第一次、第二次和第三次治疗后的临床恢复率分别为76%（170/225）、78%（43/55）和66%（8/12）。在221头恢复的奶牛中，有184头最终怀孕。其余41头奶牛主要作为繁殖问题奶牛被淘汰。首次配种受胎率为49%。每隔2周检查一次的牛群中检测到的卵巢囊肿比每隔4周检查一次的牛群更多。卵巢囊肿诊断增加可能与在某些情况下自发恢复之前检测到囊肿有关。与每隔4周检查一次的牛群相比，治疗后每隔2周检查一次的牛群中卵巢囊肿的临床恢复率较低。在2周时比在4周时更难判断GnRH诱导的卵巢囊肿黄体化和对治疗的反应。
