Department of Internal Medicine, Division of Endocrinology and Diabetology and Endocrinology Lab Platform, Medical University of Graz, 8036 Graz, Austria.
Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
Nutrients. 2023 Apr 25;15(9):2073. doi: 10.3390/nu15092073.
-peptide is produced in equimolar amounts with insulin from pancreatic beta cells, and thus is a fundamental biomarker for beta cell function. A non-invasive urinary -peptide-to-creatinine ratio (UCPCR) has attracted attention as a biomarker for metabolic conditions. However, the UCPCR as an indicative risk predictor for prediabetes is still being investigated. Methods: We aimed to characterize UCPCRs in healthy people using American Diabetes Association (ADA) criteria and to evaluate their metabolic outcomes over time. A total of 1022 participants of the Biomarkers in Personalized Medicine cohort (BioPersMed) were screened for this study. Totals of 317 healthy with normal glucose metabolism, 87 prediabetic, and 43 diabetic subjects were included. Prediabetic participants had a significantly higher UCPCR median value than healthy participants ( < 0.05). Dysglycaemia of healthy baseline participants was measured twice over 4.5 ± 0.9 years; 25% and 30% were detected with prediabetes during follow-ups, predicted by UCPCR both for the first ( < 0.05) and the second visit ( < 0.05), respectively. This is in good agreement with the negative predictive UCPCR value of 60.2% based on logistic regression. UCPCR levels were equal in both sexes. UCPCR measurements provide an indicative approach for metabolic risk, representing a potential use for prevention and monitoring of impaired glucose metabolism.
肽与胰岛素在胰岛β细胞中以等摩尔量产生，因此是β细胞功能的基本生物标志物。一种非侵入性的尿肽与肌酐比值（UCPCR）作为代谢状况的生物标志物引起了人们的关注。然而，UCPCR 作为预测糖尿病前期的指示性风险预测因子仍在研究中。方法：我们旨在使用美国糖尿病协会（ADA）标准描述健康人群中的 UCPCR，并评估其随时间推移的代谢结果。生物标志物个性化医学队列（BioPersMed）的 1022 名参与者被筛选用于本研究。共有 317 名血糖正常代谢的健康者、87 名糖尿病前期者和 43 名糖尿病者被纳入。与健康参与者相比，糖尿病前期参与者的 UCPCR 中位数显著更高（<0.05）。健康基线参与者的血糖异常在 4.5±0.9 年内测量了两次；在随访期间，25%和 30%分别被检测到患有糖尿病前期，这在第一次（<0.05）和第二次就诊（<0.05）时均通过 UCPCR 预测。这与基于逻辑回归的阴性预测 UCPCR 值 60.2%非常吻合。男女之间的 UCPCR 水平相等。UCPCR 测量提供了一种代谢风险的指示性方法，代表了预防和监测葡萄糖代谢受损的潜在用途。
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