葡萄糖耐量正常和1型糖尿病孕妇的尿C肽肌酐比值：胰岛素分泌的证据。
Urinary C peptide creatinine ratio in pregnant women with normal glucose tolerance and type 1 diabetes: evidence for insulin secretion.
作者信息
Markoska Ankica, Valaiyapathi Rajalakshmi, Thorn Chloe, Dornhorst Anne
机构信息
Faculty of Medicine, Department of Investigative Medicine , Hammersmith Hospital, Imperial College London , London , UK.
出版信息
BMJ Open Diabetes Res Care. 2017 Jan 4;5(1):e000313. doi: 10.1136/bmjdrc-2016-000313. eCollection 2017.
HYPOTHESIS
In pregnancy, urinary C peptide creatinine ratio (UCPCR) reflects endogenous insulin secretion in women with normal glucose tolerance and type 1 diabetes.
RESEARCH DESIGN AND METHODS
UCPCR and serum C peptide were measured in 90 glucose-tolerant women at 0 and 120 min during a 75 g oral glucose tolerance test (OGTT) at 28 weeks of gestation. UCPCR was measured in 2 samples obtained over 10 weeks apart in 7 pregnant women with longstanding type 1 diabetes.
RESULTS
UCPCR and serum C peptide of glucose-tolerant women were significantly correlated at 0 and 120 min (r0.675, 0.541 respectively, p<0.0001). All 7 pregnant women with type 1 diabetes had detectable first sample UCPCR (median (range) 49 (6-1038) pmol/mmol) that rose in 6 women by 477 (29-1491) pmol/mmol.
CONCLUSIONS
Detectable UCPCR in pregnant women with normal glucose tolerance and type 1 diabetes is likely to reflect endogenous insulin secretion and hence β-cell activity.
假设
在孕期，尿C肽肌酐比值（UCPCR）可反映糖耐量正常及1型糖尿病女性的内源性胰岛素分泌情况。
研究设计与方法
在妊娠28周时，对90名糖耐量正常的女性进行75克口服葡萄糖耐量试验（OGTT），分别于0分钟和120分钟时测定其UCPCR及血清C肽水平。对7名患有长期1型糖尿病的孕妇，在相隔10周采集的2份样本中测定UCPCR。
结果
糖耐量正常女性的UCPCR与血清C肽在0分钟和120分钟时显著相关（r分别为0.675和0.541，p<0.0001）。7名患有1型糖尿病的孕妇，其首份样本的UCPCR均可检测到（中位数（范围）为49（6 - 1038）pmol/mmol），其中6名孕妇的UCPCR升高了477（29 - 1491）pmol/mmol。
结论
糖耐量正常及1型糖尿病孕妇中可检测到的UCPCR可能反映内源性胰岛素分泌情况，进而反映β细胞活性。
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