Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Adv Exp Med Biol. 2023;1416:69-78. doi: 10.1007/978-3-031-29750-2_6.
Spinal meningiomas are relatively rare, but account for a significant proportion of primary spinal tumors in adults. These meningiomas can be found anywhere along the spinal column and their diagnosis is often delayed due to their slow growth and the lack of significant neurological symptoms until they reach a critical size, at which point signs of spinal cord or nerve root compression generally manifest and progress. If left untreated, spinal meningiomas can cause severe neurological deficits including rendering patients paraplegic or tetraplegic. In this chapter we will review the clinical features of spinal meningiomas, their surgical management, and detail molecular features that differentiate them from intracranial meningiomas.
脊髓脑膜瘤较为罕见,但在成人原发性脊髓肿瘤中占有相当大的比例。这些脑膜瘤可以在脊柱的任何部位发现,由于它们生长缓慢,而且在达到临界大小时,没有明显的神经症状,因此通常会出现脊髓或神经根受压的迹象,并逐渐加重,导致诊断常常被延误。如果不进行治疗,脊髓脑膜瘤可导致严重的神经功能缺损,包括使患者截瘫或四肢瘫痪。在本章中,我们将回顾脊髓脑膜瘤的临床特征、手术治疗,并详细介绍将其与颅内脑膜瘤区分开来的分子特征。