Deska-Gauthier Dylan, Hachem Laureen D, Wang Justin Z, Landry Alex P, Yefet Leeor, Gui Chloe, Ellengbogen Yosef, Badhiwala Jetan, Zadeh Gelareh, Nassiri Farshad
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Neurooncol Adv. 2024 Aug 31;6(Suppl 3):iii73-iii82. doi: 10.1093/noajnl/vdae123. eCollection 2024 Oct.
Spinal meningiomas comprise 25%-46% of all primary spinal tumors. While the majority are benign and slow-growing, when left untreated, they can result in significant neurological decline. Emerging clinical, imaging, and molecular data have begun to reveal spinal meningiomas as distinct tumor subtypes compared to their intracranial counterparts. Moreover, recent studies indicate molecular and genetic subtype heterogeneity of spinal meningiomas both within and across the classically defined WHO grades. In the current review, we focus on recent advances highlighting the epidemiological, pathological, molecular/genetic, and clinical characteristics of spinal meningiomas. Furthermore, we explore patient and tumor-specific factors that predict prognosis and postoperative outcomes. We highlight areas that require further investigation, specifically efforts aimed at linking unique molecular, genetic, and imaging characteristics to distinct clinical presentations to better predict and manage patient outcomes.
脊髓脑膜瘤占所有原发性脊髓肿瘤的25%-46%。虽然大多数是良性且生长缓慢的，但如果不进行治疗，它们会导致严重的神经功能衰退。与颅内脑膜瘤相比，新出现的临床、影像学和分子数据已开始揭示脊髓脑膜瘤是不同的肿瘤亚型。此外，最近的研究表明，脊髓脑膜瘤在经典定义的世界卫生组织分级内和分级之间都存在分子和基因亚型异质性。在本综述中，我们重点关注突出脊髓脑膜瘤的流行病学、病理学、分子/基因和临床特征的最新进展。此外，我们探讨预测预后和术后结果的患者和肿瘤特异性因素。我们强调需要进一步研究的领域，特别是旨在将独特的分子、基因和影像学特征与不同的临床表现联系起来，以更好地预测和管理患者预后的努力。
