Department of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Department of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
J Infect Public Health. 2023 Sep;16(9):1346-1360. doi: 10.1016/j.jiph.2023.06.017. Epub 2023 Jun 28.
COVID-19, caused by the novel coronavirus, has had a profound and wide-reaching impact on individuals of all age groups across the globe, including children. This review article aims to provide a comprehensive analysis of COVID-19 in children, covering essential topics such as epidemiology, transmission, pathogenesis, clinical features, risk factors, diagnosis, treatment, vaccination, and others. By delving into the current understanding of the disease and addressing the challenges that lie ahead, this article seeks to shed light on the unique considerations surrounding COVID-19 in children and contribute to a deeper comprehension of this global health crisis affecting our youngest population.
A comprehensive literature search was conducted to gather the most recent and relevant information regarding COVID-19 in children. Multiple renowned databases, including MEDLINE, PubMed, Scopus, as well as authoritative sources such as the World Health Organization (WHO), the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the National Institutes of Health (NIH) websites and others were thoroughly searched. The search included articles, guidelines, reports, clinical trials results and expert opinions published within the past three years, ensuring the inclusion of the latest research findings on COVID-19 in children. Several relevant keywords, including "COVID-19," "SARS-CoV-2," "children," "pediatrics," and related terms were used to maximize the scope of the search and retrieve a comprehensive set of articles.
Three years since the onset of the COVID-19 pandemic, our understanding of its impact on children has evolved, but many questions remain unanswered. While SAR-CoV-2 generally leads to mild illness in children, the occurrence of severe cases and the potential for long-term effects cannot be overlooked. Efforts to comprehensively study COVID-19 in children must continue to improve preventive strategies, identify high-risk populations, and ensure optimal management. By unraveling the enigma surrounding COVID-19 in children, we can strive towards safeguarding their health and well-being in the face of future global health challenges.
由新型冠状病毒引起的 COVID-19 对全球各年龄段的个体都产生了深远而广泛的影响，包括儿童。本综述文章旨在全面分析儿童 COVID-19，涵盖流行病学、传播、发病机制、临床特征、危险因素、诊断、治疗、疫苗接种等基本内容。通过深入了解该疾病并解决未来面临的挑战，本文旨在阐明儿童 COVID-19 的独特考虑因素，并促进对影响我们最年轻人群的这一全球健康危机的更深入理解。
进行了全面的文献检索，以收集有关儿童 COVID-19 的最新和最相关信息。充分利用了多个著名数据库，包括 MEDLINE、PubMed、Scopus 以及世界卫生组织（WHO）、美国食品和药物管理局（FDA）、欧洲药品管理局（EMA）、美国国立卫生研究院（NIH）网站等权威来源，对过去三年内发表的文章、指南、报告、临床试验结果和专家意见进行了彻底搜索，以确保纳入有关儿童 COVID-19 的最新研究结果。使用了“COVID-19”、“SARS-CoV-2”、“儿童”、“儿科学”等几个相关关键词，并进行了扩展，以最大限度地扩大搜索范围，检索到一套全面的文章。
自 COVID-19 大流行开始以来已经过去了三年，我们对其对儿童的影响的理解已经发展，但仍有许多问题尚未得到解答。虽然 SARS-CoV-2 通常导致儿童轻症，但不能忽视重症病例的发生和潜在的长期影响。必须继续努力全面研究儿童 COVID-19，以改进预防策略、确定高危人群并确保最佳管理。通过揭开儿童 COVID-19 之谜，我们可以努力在未来的全球健康挑战中保障他们的健康和福祉。
