The normal c-wave amplitude in rabbits.

We examined some of the problems arising when c-waves are employed in pharmacological experiments with pigmented rabbits. The cyclic variations of the c-wave are smaller in rabbit than in other species. Under our experimental conditions the c-wave amplitudes in some rabbits reached an equilibrium under intermittent stimuli, while in others they increased with time and did not reach a constant level within 3 h. The c-wave amplitude varied with the standing potential during dark adaptation. However interindividual variations made it difficult to standardize the c-waves by this change. Since the c-wave amplitudes of the right and left eyes were similar, the contralateral eye should be used as a control when drugs are administered topically. Interindividual variations of the c-wave amplitude were smaller under dim light. This method is useful in chronic pharmacological experiments when drugs are administered systemically.