Neidle S
Drugs Exp Clin Res. 1986;12(6-7):455-62.
The molecular aspects of drug-DNA interactions are presented, with special reference to anticancer drugs. The current status of, and results from, X-ray crystallographic studies on drug-oligonucleotide complexes are reviewed. The conformational features of these complexes are given in relation to the geometry of the drug binding site. Computerized molecular modelling for the rational analysis and design of DNA-binding drugs is discussed, taking the X-ray information as a starting point. Recent results from the author's laboratory on anthraquinones and anthracyclines are presented.
本文介绍了药物与DNA相互作用的分子层面，特别提及了抗癌药物。综述了药物-寡核苷酸复合物的X射线晶体学研究现状及成果。根据药物结合位点的几何结构，给出了这些复合物的构象特征。以X射线信息为起点，讨论了用于合理分析和设计DNA结合药物的计算机分子建模。还介绍了作者实验室关于蒽醌和蒽环类药物的最新研究成果。
