Burzynski S R, Mohabbat M O
Drugs Exp Clin Res. 1986;12 Suppl 1:73-5.
Antineoplaston A2, 25 mg/ml, was administered to mice in the form of daily intraperitoneal injections for 270 days. The mice were further observed up to 365 days. The total number of mice included in the experiment was 160, both sexes being represented equally. The animals were divided into four groups, each group containing 20 males and 20 females. The first group received 107 mg/kg body weight per day of Antineoplaston A2, the second 646 mg/kg and the third one 1300 mg/kg daily. The fourth group was kept as the control. Two male and two female mice were sacrificed on days 30, 60, 90, 180 and 365 and underwent complete physical, gross pathological and microscopic examination. No toxic effects were observed. In conclusion, daily intraperitoneal injections of Antineoplaston A2 to mice at the dosage level of 107 mg/kg, 646 mg/kg and 1300 mg/kg for 270 days did not produce any toxic effect.
以每天腹腔注射的形式，给小鼠注射25毫克/毫升的抗瘤酮A2，持续270天。对这些小鼠进一步观察至365天。实验中使用的小鼠总数为160只，雌雄数量均等。这些动物被分成四组，每组包含20只雄性和20只雌性。第一组每天接受107毫克/千克体重的抗瘤酮A2，第二组为646毫克/千克，第三组为1300毫克/千克。第四组作为对照组。在第30天、60天、90天、180天和365天，处死两只雄性和两只雌性小鼠，并进行全面的体格检查、大体病理学检查和显微镜检查。未观察到毒性作用。总之，以107毫克/千克、646毫克/千克和1300毫克/千克的剂量水平，每天给小鼠腹腔注射抗瘤酮A2，持续270天，未产生任何毒性作用。
