Armstrong D K, Dasta J F, Reilley T E, Tallman R D
Drug Intell Clin Pharm. 1986 Jul-Aug;20(7-8):543-6. doi: 10.1177/106002808602000704.
Increasing renal blood flow (RBF) by the administration of low-dose dopamine is one mechanism to increase urine output in oliguric patients. This response is mediated in part by stimulation of dopaminergic receptors in the kidney, which could be attenuated by the dopamine blocker haloperidol. We evaluated this interaction by administering both drugs in clinically used doses to six anesthetized mongrel dogs. A dopamine regimen of 2.5 micrograms/kg/min significantly increased RBF along with cardiac output and stroke volume. Simultaneous administration of haloperidol 50 micrograms/kg iv did not influence the ability of low-dose dopamine to increase RBF. Although haloperidol is an antagonist of dopaminergic receptors, the increase in RBF associated with low-dose dopamine is maintained when intravenous haloperidol is concurrently administered to dogs.
通过给予小剂量多巴胺来增加肾血流量（RBF）是增加少尿患者尿量的一种机制。这种反应部分是由肾脏中多巴胺能受体的刺激介导的，而多巴胺阻滞剂氟哌啶醇可能会减弱这种反应。我们通过给6只麻醉的杂种狗给予临床常用剂量的这两种药物来评估这种相互作用。2.5微克/千克/分钟的多巴胺给药方案显著增加了肾血流量以及心输出量和每搏输出量。静脉注射50微克/千克的氟哌啶醇同时给药并不影响小剂量多巴胺增加肾血流量的能力。尽管氟哌啶醇是多巴胺能受体的拮抗剂，但当给狗同时静脉注射氟哌啶醇时，与小剂量多巴胺相关的肾血流量增加得以维持。
