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眼睑水肿可能是传染性单核细胞增多症病程中泪腺炎的一个体征。

Eyelid Edema May Be as a Sign of Dacryoadenitis in the Course of Epstein-Barr Virus Infectious Mononucleosis.

作者信息

Capelli Marco

机构信息

Endoscopy and Pathophysiology Upper Airway Unit, "Villa Antonella" Clinic, Viale Buonarroti 68, Codogno (Lo), Italy. Email:

出版信息

J Med Cases. 2023 Jun;14(6):208-212. doi: 10.14740/jmc4114. Epub 2023 Jun 29.

DOI:10.14740/jmc4114
PMID:37435102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10332871/
Abstract

Epstein-Barr virus (EBV) is a widespread virus that causes frequent, in many cases asymptomatic, infections. Mononucleosis is the most frequent clinical syndrome encountered during EBV infection. In rare cases, the disease can present at the onset with atypical signs that make an immediate diagnostic classification difficult. An example in this sense is the onset of dacryoadenitis with consequent eyelid edema. In these cases, it is difficult to immediately recognize this sign as referable to mononucleosis and it appears necessary to carry out a series of analyses aimed at excluding any other edematous causes. We describe below a clinical case of dacryoadenitis in the course of infectious mononucleosis and a review of similar cases described in the literature starting from 1952 (the year in which this sign was described for the first time). We counted 28 cases before ours, thus confirming the exceptional nature of this event.

摘要

爱泼斯坦-巴尔病毒(EBV)是一种广泛传播的病毒,常引发感染,许多情况下并无症状。传染性单核细胞增多症是EBV感染最常见的临床综合征。在罕见情况下,疾病起病时可能出现非典型症状,难以立即进行诊断分类。泪腺炎伴眼睑水肿起病就是这样一个例子。在这些病例中,很难立即将此症状认定为与传染性单核细胞增多症相关,似乎有必要进行一系列分析以排除任何其他导致水肿的原因。我们在下文描述了一例传染性单核细胞增多症病程中出现泪腺炎的临床病例,并回顾了自1952年(此症状首次被描述的年份)以来文献中描述过的类似病例。在我们之前统计到28例病例,从而证实了这一事件的特殊性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c6a/10332871/84f7819ed8de/jmc-14-208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c6a/10332871/84f7819ed8de/jmc-14-208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c6a/10332871/84f7819ed8de/jmc-14-208-g001.jpg

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本文引用的文献

1
A Protracted Course of Periorbital Oedema in Infectious Mononucleosis Caused by Epstein-Barr Virus.由爱泼斯坦-巴尔病毒引起的传染性单核细胞增多症导致的长期眶周水肿病程
Infect Dis Rep. 2022 Nov 23;14(6):942-945. doi: 10.3390/idr14060092.
2
Hoagland sign in infectious mononucleosis.传染性单核细胞增多症中的霍格兰征。
BMJ Case Rep. 2022 Nov 16;15(11):e252839. doi: 10.1136/bcr-2022-252839.
3
Bilateral upper eyelid swelling (Hoagland sign) in Epstein-Barr infectious mononucleosis: prospective experience.传染性单核细胞增多症中双侧上眼睑肿胀(Hoagland 征):前瞻性经验。
Infection. 2023 Apr;51(2):471-474. doi: 10.1007/s15010-022-01932-6. Epub 2022 Oct 12.
4
Hoagland sign: bilateral upper eyelid oedema.霍格兰征:双侧上睑水肿。
BMJ Case Rep. 2022 Jun 22;15(6):e250857. doi: 10.1136/bcr-2022-250857.
5
Anterior segment involvement in Epstein-Barr virus: a review.眼表前段的 EBV 感染:综述。
Acta Ophthalmol. 2022 Aug;100(5):e1052-e1060. doi: 10.1111/aos.15061. Epub 2021 Nov 11.
6
Febrile palpebral edema.发热性睑水肿
JAAD Case Rep. 2021 Jun 14;14:59-61. doi: 10.1016/j.jdcr.2021.06.015. eCollection 2021 Aug.
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Probiotics in the add-on treatment of pharyngotonsillitis: a clinical experience.益生菌辅助治疗咽扁桃体炎的临床体会。
J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):11-18.
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A probiotic mixture in patients with upper respiratory diseases: the point of view of the otorhinolaringologist.益生菌混合物在呼吸道疾病患者中的应用:耳鼻喉科医生的观点。
J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):5-10.
9
Infectious mononucleosis with eyelid edema and palatal petechiae.伴有眼睑水肿和腭部瘀点的传染性单核细胞增多症。
Korean J Intern Med. 2021 Jul;36(4):1027-1028. doi: 10.3904/kjim.2020.350. Epub 2021 Jan 8.
10
Young female patient with bilateral periorbital edema.
Eur J Intern Med. 2020 May;75:93-94. doi: 10.1016/j.ejim.2020.02.013. Epub 2020 Mar 5.