Tien Carolyn Shan-Yeu, Liew Ian Tatt, Ho Quan Yao, Thangaraju Sobhana, Rahman Maslinna Binte Abdul, Lee Constance, Leah Nicole Chelsi Xin Hui, He Xia, Siew Li Ting, Kee Terence Yi Shern
Department of Renal Medicine, Singapore General Hospital, Singapore.
Renal Transplant Program, SingHealth Duke-NUS Transplant Centre, Singapore.
Korean J Transplant. 2023 Jun 30;37(2):95-102. doi: 10.4285/kjt.23.0020.
The coronavirus disease 2019 (COVID-19) pandemic curtailed transplant activities worldwide, driven by concerns about increased COVID-19-related mortality among kidney transplant recipients (KTRs), infections originating from donors, and decreased availability of surgical and intensive care resources as healthcare resources are reallocated for pandemic response. We examined the outcomes of KTRs at our center before and during the COVID-19 pandemic.
We conducted a retrospective single-center cohort study examining the characteristics and outcomes of patients undergoing kidney transplantation during two periods January 1, 2017 to December 31, 2019 (pre-COVID-19 era) and January 1, 2020 to June 30, 2022 (COVID-19 era). We reviewed perioperative and COVID-19 infection-related outcomes in both groups.
A total of 114 transplants were performed during the pre-COVID-19 era, while 74 transplants were conducted during the COVID-19 era. No differences in baseline demographics were observed. Additionally, there were no significant differences in perioperative outcomes, except for a longer cold ischemia time during the COVID-19 era. However, this did not result in an increased incidence of delayed graft function. Among the KTRs infected with COVID-19 during the pandemic era, no severe complications such as pneumonia, acute kidney injury, or death were reported.
With the global transition to an endemic phase of COVID-19, it is imperative to revitalize organ transplant activities. Effective containment workflow, good vaccination uptake, and prompt COVID-19 treatment are essential to ensure that transplants can proceed safely.
2019年冠状病毒病（COVID-19）大流行减少了全球范围内的移植活动，原因是担心肾移植受者（KTR）中与COVID-19相关的死亡率增加、供体来源的感染以及随着医疗资源重新分配以应对大流行而导致手术和重症监护资源的可用性下降。我们研究了COVID-19大流行之前和期间我们中心KTR的结局。
我们进行了一项回顾性单中心队列研究，考察了2017年1月1日至2019年12月31日（COVID-19大流行前时期）和2020年1月1日至2022年6月30日（COVID-19大流行时期）两个时间段接受肾移植患者的特征和结局。我们回顾了两组患者的围手术期和COVID-19感染相关结局。
在COVID-19大流行前时期共进行了114例移植手术，而在COVID-19大流行时期进行了74例移植手术。未观察到基线人口统计学特征的差异。此外，围手术期结局没有显著差异，除了COVID-19大流行时期的冷缺血时间更长。然而，这并未导致移植肾功能延迟发生率增加。在大流行时期感染COVID-19的KTR中，未报告肺炎、急性肾损伤或死亡等严重并发症。
随着全球向COVID-19地方流行阶段过渡，振兴器官移植活动势在必行。有效的防控工作流程、良好的疫苗接种率以及及时的COVID-19治疗对于确保移植手术能够安全进行至关重要。
