使用生物源溶剂蒎烷通过微波辅助合成喹唑啉酮及其前体。
Convergent micro-wave assisted synthesis of quinazolinone and its precursor using the bio-sourced solvent pinane.
作者信息
Richieu Antoine, Bertrand Philippe
机构信息
Institut de Chimie des Milieux et Matériaux de Poitiers, UMR CNRS 7285 4 rue Michel Brunet, TSA 51106, B27 86073 Poitiers France
出版信息
RSC Adv. 2023 Jul 10;13(30):20646-20650. doi: 10.1039/d3ra03702a. eCollection 2023 Jul 7.
Abstract
A general microwave synthesis of 4-oxo-3,4-dihydroquinazolin-2-yl propanoic acids and their diamide precursors from the corresponding substituted benzamide and succinic anhydride is described, using pinane as a sustainable solvent that favors the cyclization step. The conditions are some of the most simple and cost effective reported.
摘要
描述了一种从相应的取代苯甲酰胺和琥珀酸酐通过通用微波合成4-氧代-3,4-二氢喹唑啉-2-基丙酸及其二酰胺前体的方法，使用蒎烷作为有利于环化步骤的可持续溶剂。这些条件是所报道的最简单且最具成本效益的条件之一。
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