Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, China.
Key Laboratory of Cardiovascular Diseases of Yunnan Province, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Central Laboratory of Yan'an Hospital Affiliated to Kunming Medical University, Kunming, China.
J Cell Physiol. 2023 Sep;238(9):2010-2025. doi: 10.1002/jcp.31078. Epub 2023 Jul 12.
Starch-binding domain-containing protein 1 (STBD1) is a glycogen-binding protein discovered in skeletal muscle gene differential expression that is pivotal to cellular energy metabolism. Recent studies have indicated that STBD1 is involved in many physiological processes, such as glycophagy, glycogen accumulation, and lipid droplet formation. Moreover, dysregulation of STBD1 causes multiple diseases, including cardiovascular disease, metabolic disease, and even cancer. Deletions and/or mutations in STBD1 promote tumorigenesis. Therefore, STBD1 has garnered considerable interest in the pathology community. In this review, we first summarized the current understanding of STBD1, including its structure, subcellular localization, tissue distribution, and biological functions. Next, we examined the roles and molecular mechanisms of STBD1 in related diseases. Based on available research, we discussed the novel function and future of STBD1, including its potential application as a therapeutic target in glycogen-related diseases. Given the significance of STBD1 in energy metabolism, an in-depth understanding of the protein is crucial for understanding physiological processes and developing therapeutic strategies for related diseases.
淀粉结合域蛋白 1（STBD1）是在骨骼肌基因差异表达中发现的一种糖原结合蛋白，对细胞能量代谢至关重要。最近的研究表明，STBD1 参与许多生理过程，如糖异生、糖原积累和脂滴形成。此外，STBD1 的失调会导致多种疾病，包括心血管疾病、代谢疾病，甚至癌症。STBD1 的缺失和/或突变会促进肿瘤的发生。因此，STBD1 在病理学领域引起了相当大的关注。在这篇综述中，我们首先总结了 STBD1 的当前认识，包括其结构、亚细胞定位、组织分布和生物学功能。接下来，我们研究了 STBD1 在相关疾病中的作用和分子机制。根据现有研究，我们讨论了 STBD1 的新功能和未来，包括其作为糖原相关疾病治疗靶点的潜在应用。鉴于 STBD1 在能量代谢中的重要性，深入了解该蛋白对于理解生理过程和开发相关疾病的治疗策略至关重要。
