Friedrich W, Lisse K, Körner H, Wilken T
Exp Clin Endocrinol. 1986 Jun;87(1):1-7. doi: 10.1055/s-0029-1210515.
The pattern of follicular and luteal phase levels of serum estradiol-17 beta (E2) and progesterone (P) are compared between 5 conception (group P) and 27 nonconception (group N) cycles of patients undergoing in vitro fertilization and embryo transfer. Follicle growth was induced with human pituitary gonadotropin and controlled by daily ovarian ultrasonography measuring the follicular diameters. Group N has significantly (p less than 0.025) higher E2 levels from day -10 up to d-6 as compared with the group P. The day of laparoscopy is designated day 0. In group N the length of E2 phase with E2 levels, exceeding 1.84 nmol/l (500 pg/ml) serum, is greater (p less than 0.001) than in group P 6.9 and 5.6 days, respectively. It is suggested that modifications occur in the endometrium caused by high E2 levels acting for a long time, which disturb the implantation of transferred embryos. No significant differences exist between group N and P, if the diameters of the largest follicle or the mean diameters of the secondary follicles or the number of follicles with a diameter greater than 14 mm are compared. No significant correlations were found between these variables and the E2 levels. A significant correlation (r = 0.85, 14 patients) exists between the E2 rise and the increase of follicular diameters.
比较了接受体外受精和胚胎移植患者的5个受孕周期（P组）和27个未受孕周期（N组）中血清雌二醇-17β（E2）和孕酮（P）的卵泡期和黄体期水平模式。用人垂体促性腺激素诱导卵泡生长，并通过每日超声检查测量卵泡直径来进行控制。与P组相比，N组从第-10天至第-6天的E2水平显著更高（p<0.025）。腹腔镜检查日定为第0天。在N组中，E2水平超过1.84 nmol/L（500 pg/ml）血清的E2期长度分别比P组多6.9天和5.6天（p<0.001）。提示长时间高水平E2作用于子宫内膜会引起改变，从而干扰移植胚胎的着床。如果比较最大卵泡直径、次级卵泡平均直径或直径大于14 mm的卵泡数量，N组和P组之间没有显著差异。这些变量与E2水平之间未发现显著相关性。E2升高与卵泡直径增加之间存在显著相关性（r = 0.85，14例患者）。
