原发性甲状旁腺功能亢进患者手术前后肾小管对磷的最大重吸收能力
Renal tubular maximum reabsorptive capacity for phosphate in patients with primary hyperparathyroidism before and after operation.
作者信息
Broulik P D, Pacovský V
出版信息
Exp Clin Endocrinol. 1986 Jun;87(1):43-7. doi: 10.1055/s-0029-1210521.
A determination was made of the renal tubular maximum reabsorptive capacity for phosphate (expressed as a function of the glomerular filtrate) in 33 patients with primary hypercalcaemic hyperparathyroidism and 30 control normal subjects. The difference between patients and controls for the maximum renal tubular reabsorptive capacity for phosphate (patients 0.526 +/- 0.16 mmol/l, controls 1.010 +/- 0.14 mmol/l) was highly significant (p less than 0.001). Successful removal of a single parathyroid adenoma in 19 patients was associated with a highly significant rise in the renal tubular maximum reabsorptive capacity for phosphate (1.005 +/- 0.21 mmol/l, p less than 0.001). We did not find any correlation between the renal tubular maximum reabsorptive capacity for phosphate and serum immunoreactive PTH level. Low renal tubular maximum reabsorptive capacity for phosphate in the presence of hypercalcaemia is highly suggestive of primary hyperparathyroidism.
对33例原发性高钙血症性甲状旁腺功能亢进患者和30例对照正常受试者的肾小管对磷酸盐的最大重吸收能力（以肾小球滤过液的函数表示）进行了测定。患者与对照者在肾小管对磷酸盐的最大重吸收能力方面的差异（患者为0.526±0.16 mmol/l，对照者为1.010±0.14 mmol/l）具有高度显著性（p<0.001）。19例患者成功切除单个甲状旁腺腺瘤后，肾小管对磷酸盐的最大重吸收能力显著升高（1.005±0.21 mmol/l，p<0.001）。我们未发现肾小管对磷酸盐的最大重吸收能力与血清免疫反应性甲状旁腺激素水平之间存在任何相关性。高钙血症情况下肾小管对磷酸盐的最大重吸收能力降低高度提示原发性甲状旁腺功能亢进。
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