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药理剂量的碘番酸及甲状腺素对猪肝脏和肾脏中5-及5'-单脱碘作用的影响

Influence of pharmacological doses of iopanoic acid and thyroxine 5- and 5'-monodeiodination in liver and kidney of the pig.

作者信息

Slebodziński A B, Brzezińska-Slebodzinska E, Dudzińska J

出版信息

Exp Clin Endocrinol. 1986 Jun;87(1):63-8. doi: 10.1055/s-0029-1210524.

DOI:10.1055/s-0029-1210524
PMID:3743648
Abstract

Short-lasting (24-48 h) IOP administration to growing pigs causes the inhibition of both 5- and 5'-thyroxine monodeiodination in the liver and the kidney. After administration of IOP in vivo or into tissue homogenates, the inhibition of T4 to T3 conversion was stronger than that of T4 to rT3. The inhibitory effect was related to the thyroid hormones concentration in serum and to the age of animals.

摘要

对生长猪进行短期（24 - 48小时）的碘普罗胺给药会抑制肝脏和肾脏中5-和5'-甲状腺素单脱碘作用。在体内或向组织匀浆中给予碘普罗胺后，T4向T3转化的抑制作用强于T4向反T3的转化。这种抑制作用与血清中的甲状腺激素浓度以及动物年龄有关。

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Influence of pharmacological doses of iopanoic acid and thyroxine 5- and 5'-monodeiodination in liver and kidney of the pig.药理剂量的碘番酸及甲状腺素对猪肝脏和肾脏中5-及5'-单脱碘作用的影响
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