Department of Chemistry, College of Sciences, Shanghai University, Shanghai, 200444, PR China.
J Fluoresc. 2024 May;34(3):1007-1014. doi: 10.1007/s10895-023-03333-w. Epub 2023 Jul 12.
A facile method which combines the advantages of carbon quantum dots and molecular imprinting technology to design a fluorescence molecular imprinting sensor for the high sensitivity and selective detection of chloramphenicol. The fluorescent molecule imprinted polymers are synthesized by sol-gel polymerization using carbon quantum dots as functional monomers and fluorescent sources, TEOS as crosslinkers, breaking with the traditional understanding of an additional functional monomer. Under optimal experimental, as the concentration of chloramphenicol increases, the fluorescence intensity of the fluorescence molecule imprinting sensor gradually decreases. The concentration of chloramphenicol is linear in the range of 5-100 µg/L and the detection limit is 1 µg/L (N/S = 3). The sensor is able to detect chloramphenicol in milk, enabling the application of real samples. The results show that this work provides an easy method to preparing fluorescent molecular imprinting sensors for the detection of chloramphenicol in milk.
一种简便的方法，结合了碳量子点和分子印迹技术的优点，设计了一种用于氯霉素高灵敏度和选择性检测的荧光分子印迹传感器。荧光分子印迹聚合物通过溶胶-凝胶聚合合成，以碳量子点为功能单体和荧光源，TEOS 为交联剂，打破了传统的外加功能单体的认识。在最佳实验条件下，随着氯霉素浓度的增加，荧光分子印迹传感器的荧光强度逐渐降低。氯霉素的浓度在 5-100μg/L 范围内呈线性关系，检测限为 1μg/L（N/S=3）。该传感器能够检测牛奶中的氯霉素，实现了实际样品的应用。结果表明，该工作为制备用于牛奶中氯霉素检测的荧光分子印迹传感器提供了一种简便的方法。
