Charlon C, Luu-Duc C, Huguet F, Gérard P, Narcisse G
Farmaco Sci. 1986 Aug;41(8):586-96.
Sixteen fluorinated phenylethylamines analogous to catecholamine were obtained by fluoration from the corresponding amino-alcohols. The biological activity of the compounds was evaluated by determining their affinity for the central adrenergic receptors of rat brain membranes and by measuring the monoamine synaptosomal uptake. These compounds significantly inhibited serotonine uptake, but they showed no affinity for amphetaminergic binding sites.
通过对相应氨基醇进行氟化反应，得到了16种类似于儿茶酚胺的氟化苯乙胺。通过测定这些化合物对大鼠脑膜中枢肾上腺素能受体的亲和力以及测量单胺突触体摄取来评估其生物活性。这些化合物显著抑制血清素摄取，但对苯丙胺能结合位点无亲和力。
