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Th1 样调节性 T 细胞整装待发以抑制抗肿瘤免疫。

Th1-like Treg cells are dressed to suppress anti-tumor immunity.

机构信息

Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, NH, USA.

Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, NH, USA.

出版信息

Immunity. 2023 Jul 11;56(7):1437-1439. doi: 10.1016/j.immuni.2023.06.014.

DOI:10.1016/j.immuni.2023.06.014
PMID:37437535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11229784/
Abstract

Mechanisms of Th1-like Treg suppression are unknown in cancer. Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to potently suppress anti-tumor immunity.

摘要

在癌症中，Th1 样调节性 T 细胞（Treg）抑制的机制尚不清楚。Ayala 等人和 Zagorulya 等人在《免疫》杂志上的两项研究表明，Th1 样 Treg 细胞与肿瘤和引流淋巴结中的 1 型树突状细胞相互作用，从而强烈抑制抗肿瘤免疫。

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本文引用的文献

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CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8 T cell antitumor immunity.CXCR3 在调节性 T 细胞中的表达驱动其与肿瘤中 I 型树突状细胞的相互作用，从而限制 CD8 T 细胞的抗肿瘤免疫。
Immunity. 2023 Jul 11;56(7):1613-1630.e5. doi: 10.1016/j.immuni.2023.06.003. Epub 2023 Jun 30.
2
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy.肿瘤浸润调节性T细胞作为癌症免疫治疗的靶点。
Cancer Cell. 2023 Mar 13;41(3):450-465. doi: 10.1016/j.ccell.2023.02.014.
3
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
免疫细胞的脂质过氧化作用与癌症。
Front Immunol. 2024 Jan 8;14:1322746. doi: 10.3389/fimmu.2023.1322746. eCollection 2023.
组织特异性干扰素-γ丰度驱动调节性 T 细胞抑制 DC1 介导的针对肺癌的细胞毒性 T 细胞的初始激活。
Immunity. 2023 Feb 14;56(2):386-405.e10. doi: 10.1016/j.immuni.2023.01.010. Epub 2023 Feb 2.
4
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.阻断 CTLA-4 依赖性反馈回路可扩增肿瘤相关 Treg 细胞。
Cell. 2021 Jul 22;184(15):3998-4015.e19. doi: 10.1016/j.cell.2021.05.027. Epub 2021 Jun 21.
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Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses.Tbet 阳性调节性 T 细胞在存在持续肿瘤特异性 1 型 T 细胞应答的口咽癌中积累。
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