Th1 样调节性 T 细胞整装待发以抑制抗肿瘤免疫。

Th1-like Treg cells are dressed to suppress anti-tumor immunity.

机构信息

Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, NH, USA.

出版信息

Immunity. 2023 Jul 11;56(7):1437-1439. doi: 10.1016/j.immuni.2023.06.014.

DOI:10.1016/j.immuni.2023.06.014

PMID:37437535

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11229784/

Abstract

Mechanisms of Th1-like Treg suppression are unknown in cancer. Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to potently suppress anti-tumor immunity.

摘要

在癌症中，Th1 样调节性 T 细胞（Treg）抑制的机制尚不清楚。Ayala 等人和 Zagorulya 等人在《免疫》杂志上的两项研究表明，Th1 样 Treg 细胞与肿瘤和引流淋巴结中的 1 型树突状细胞相互作用，从而强烈抑制抗肿瘤免疫。