Department of Gynecology, Chongqing Haifu Hospital, Chongqing, P.R. China.
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, P.R. China.
Int J Hyperthermia. 2023;40(1):2234674. doi: 10.1080/02656736.2023.2234674.
To describe the reproductive outcomes of patients with diffuse uterine leiomyomatosis (DUL) treated with high-intensity focused ultrasound (HIFU) ablation.
Three patients of reproductive age with DUL who underwent HIFU treatment were enrolled, all of whom had a strong desire to become pregnant. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray radiography, ultrasound, and magnetic resonance imaging (MRI) examinations after routine medical history collection and physical examination. The treatment time, treatment power, sonication time, and adverse events were recorded. One day after HIFU, MRI was performed to evaluate treatment efficacy. The patients were scheduled for follow-up at 3-, 6-, 12-, and 24-month after HIFU treatment.
All the three patients completed HIFU treatment successfully without any major complication. Uterine size and menstrual volume significantly decreased with the combination of medical and HIFU treatments. The shrinkage rate of uterine volume was 31-44% and the menstrual volume reduced by 1/2 or returned to normal at 3 months post-HIFU. Three patients had successful conceptions between 3 and 11 months after HIFU with healthy deliveries. No uterine rupture occurred during pregnancy and delivery.
HIFU ablation may help achieve a successful pregnancy in patients with DUL.
描述接受高强度聚焦超声（HIFU）消融治疗的弥漫性子宫平滑肌瘤病（DUL）患者的妊娠结局。
纳入 3 名有生育要求的 DUL 育龄期患者，均接受 HIFU 治疗。所有患者均在常规病史采集和体格检查后接受常规实验室检查、心电图（ECG）、胸部 X 线摄片、超声和磁共振成像（MRI）检查。记录治疗时间、治疗功率、超声时间和不良事件。HIFU 治疗后第 1 天行 MRI 评估治疗效果。HIFU 治疗后 3、6、12 和 24 个月时对患者进行随访。
所有 3 例患者均成功完成 HIFU 治疗，无严重并发症。结合药物和 HIFU 治疗，子宫大小和月经血量显著减少。子宫体积的缩小率为 31%-44%，HIFU 治疗后 3 个月月经血量减少 1/2 或恢复正常。3 例患者 HIFU 治疗后 3-11 个月成功受孕并自然分娩，妊娠和分娩期间未发生子宫破裂。
HIFU 消融可能有助于 DUL 患者实现成功妊娠。
