硫代钼酸盐对绵羊血浆铜蓝蛋白的可逆抑制作用。

Reversible inhibition of ovine ceruloplasmin by thiomolybdates.

作者信息

Kelleher C A, Mason J

出版信息

Int J Biochem. 1986;18(7):629-35. doi: 10.1016/0020-711x(86)90293-4.

Abstract

The synthesis and purification of the sodium salts of di (MoO2S2(2-)), tri (MoOS3(2-)) and tetra (MoOS4(2-)) thiomolybdate is reported. All three compounds were reversible inhibitors of the ovine ceruloplasmin (Cp) catalysed oxidation of O-dianisidine. Na2MoO2S2 inhibited via a non-competitive mechanism whereas Na2MoOS3 showed mixed non competitive and Na2MoS4 competitive mechanisms. All showed upward curving slope replots. Molybdenum trisulfide (MoS3) was synthesized and displayed mixed type inhibition kinetics but with a linear slope replot. Preliminary evidence suggested that both MoOS3(2-) and MoS4(2-) may also be substrates for ovine Cp.

摘要

报道了二硫代钼酸根（MoO₂S₂²⁻）、三硫代钼酸根（MoOS₃²⁻）和四硫代钼酸根（MoOS₄²⁻）钠盐的合成与纯化。这三种化合物都是绵羊铜蓝蛋白（Cp）催化邻联茴香胺氧化反应的可逆抑制剂。Na₂MoO₂S₂通过非竞争性机制抑制，而Na₂MoOS₃表现出混合型非竞争性机制，Na₂MoS₄表现出竞争性机制。所有化合物的重绘曲线均呈向上弯曲。合成了三硫化钼（MoS₃），其表现出混合型抑制动力学，但重绘曲线呈线性。初步证据表明，MoOS₃²⁻和MoS₄²⁻也可能是绵羊Cp的底物。