Pechan P, Shapiro D Y, Tracey M
Differentiation. 1986;31(2):106-10. doi: 10.1111/j.1432-0436.1986.tb00390.x.
It has been proposed that H-Y antigen is the synthetic product of sex-determining genes, and that H-Y antigen controls ontogenetic differentiation of the heterogametic sex throughout vertebrates. The coral-reef fish Anthias squamipinnis is a protogynous hermaphrodite in which all individuals mature initially as females. Males result when adult females change sex as a consequence of alterations in behavioral interactions within social groups. Three assay methods were used to measure H-Y antigen levels in the spleens, gonads, and epidermal tissue of 16 adult females and in 16 males that had been induced to change sex from a prior female phase by the removal of a pre-existing male from each of 16 social groups. In 15 male-female pairs, the H-Y antigen levels were higher in male than in female spleen, gonad, and epidermis tissues. The precise temporal relationship between the onset of sex change and the increase in the H-Y antigen level was not examined. If, as we strongly suspect, the temporal relationship proves to be close, the inference will be that the behavioral cues inducing sex change also influence the synthetic activity of genes controlling H-Y antigen production.
有人提出，H-Y抗原是性别决定基因的合成产物，并且H-Y抗原控制着整个脊椎动物中异配性别的个体发育分化。珊瑚礁鱼类鞍带石斑鱼是一种雌性先熟的雌雄同体鱼类，所有个体最初都作为雌性成熟。当成年雌性由于社会群体内行为相互作用的改变而发生性别变化时，就会产生雄性。使用三种检测方法来测量16只成年雌性以及通过从16个社会群体中各移除一只已有的雄性而被诱导从先前的雌性阶段转变为雄性的16只雄性的脾脏、性腺和表皮组织中的H-Y抗原水平。在15对雌雄配对中，雄性脾脏、性腺和表皮组织中的H-Y抗原水平高于雌性。性别变化开始与H-Y抗原水平升高之间的确切时间关系未进行研究。如果正如我们强烈怀疑的那样，时间关系被证明是密切的，那么推断将是诱导性别变化的行为线索也会影响控制H-Y抗原产生的基因的合成活性。
