Müller U, Wolf U
Differentiation. 1979;14(3):185-7. doi: 10.1111/j.1432-0436.1979.tb01027.x.
Anti-H-Y antiserum, raised in highly inbred rats, is absorbed by gonadal cells of various species of fish. This cross-reactivity proved to be restricted to the male sex in the cyprinodont species Lebistes and Xiphophorus, known to have the XX/XY mechanism of sex determination. In members of the more primitive fish orders Isospondyli and Ostariophysi, cross-reactivity was shown to occur as well, but the amount of antiserum absorbed was very similar in both sexes. An antigen cross-reacting with mammalian anti-H-Y antiserum is assumed to exist in fish similar to that found in higher vertebrates. If this is true, this antigen may have been shared originally by both sexes. However, during evolution, its expression has become restricted to the heterogametic sex.
在高度近交的大鼠中产生的抗H-Y抗血清可被多种鱼类的性腺细胞吸收。在已知具有XX/XY性别决定机制的鲤齿目物种虹鳉和剑尾鱼中，这种交叉反应被证明仅限于雄性。在更原始的鱼类目硬骨鱼和骨鳔鱼的成员中，也显示出交叉反应，但两性吸收的抗血清量非常相似。假定鱼类中存在一种与哺乳动物抗H-Y抗血清发生交叉反应的抗原，类似于在高等脊椎动物中发现的抗原。如果这是真的，这种抗原可能最初是两性共有的。然而，在进化过程中，其表达已局限于异配性别。
