视网膜神经节细胞疾病中的轴突运输缺陷。

Axonal Transport Defects in Retinal Ganglion Cell Diseases.

机构信息

Molecular Biology, Genetics and Bioengineering Program, Sabanci University, Istanbul, Turkey.

Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul, Turkey.

出版信息

Adv Exp Med Biol. 2023;1415:223-227. doi: 10.1007/978-3-031-27681-1_32.

DOI:10.1007/978-3-031-27681-1_32

PMID:37440037

Abstract

For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transport defects usually precede axonal degeneration and RGC loss in disease models. To date, the main causes of axonal transport defects have not been fully understood. Therefore, elucidation of the mechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degeneration with a focus on axonal transport.

摘要

为了维持和存活视网膜神经节细胞（RGCs），轴突运输是基础。轴突运输缺陷可导致严重的神经病变，引起神经元丢失。在疾病模型中，轴突运输缺陷通常先于轴突变性和 RGC 丢失。迄今为止，轴突运输缺陷的主要原因尚未完全阐明。因此，阐明导致运输缺陷的机制将有助于我们开发新的治疗靶点和早期诊断工具。在这篇综述中，我们重点介绍了轴突运输，概述了视神经病变和轴突变性。