虚拟身心项目对讲英语的国际神经纤维瘤病成年人的韧性因素的影响：一项随机临床试验的二次分析。
The impact of a virtual mind-body program on resilience factors among international English-speaking adults with neurofibromatoses: secondary analysis of a randomized clinical trial.
机构信息
Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, 1 Bowdoin Sq, Boston, MA, 02114, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
出版信息
J Neurooncol. 2023 Jul;163(3):707-716. doi: 10.1007/s11060-023-04389-1. Epub 2023 Jul 13.
PURPOSE
To test the effects of the Relaxation Response Resiliency Program - Neurofibromatosis (3RP-NF), a mind-body resilience program for people with NF, on resilience factors from baseline to post-treatment and 6- and 12-month follow-up.
METHODS
This is a secondary analysis of a fully powered randomized clinical trial (RCT) of 3RP-NF and health education control (HEP-NF). We recruited adults with NF1, NF2, or schwannomatosis who reported stress or difficulty coping with NF symptoms. Both conditions received 8 weekly 90-minute group sessions; 3RP-NF focused on building resilience skills. We measured resilience factors via the Measure of Current Status-A (adaptive coping), Cognitive and Affective Mindfulness Scale-Revised (mindfulness), Gratitude Questionnaire-6 (gratitude), Life Orientation Test Optimism Scale (optimism), and Medical Outcomes Study Social Support Survey (perceived social support) at baseline, post-intervention, and 6- and 12-month follow-up. We used linear mixed models with completely unstructured covariance across up to four repeated measurements (baseline, post-treatment, and 6- and 12-month follow-up) to investigate treatment effects on resilience factors.
RESULTS
We enrolled 228 individuals (M=42.7, SD = 14.6; 74.5% female; 87.7% White; 72.8% NF1, 14.0% NF2, 13.2% schwannomatosis). Within groups, both 3RP-NF and HEP-NF showed statistically significant improvements in all outcomes across timepoints. 3RP-NF showed significantly greater improvement in adaptive coping compared to HEP-NF from baseline to post-intervention and baseline to 6 months (M= 0.29; 95% CI 0.13-0.46; p < 0.001; M= 0.25; 95% CI 0.07-0.33; p = 0.005); there were no other between-group differences amongst the remaining resilience factors.
CONCLUSION
3RP-NF showed promise in sustainably improving coping abilities amongst people with NF.
TRIAL REGISTRATION INFORMATION
ClinicalTrials.gov Identifier: NCT03406208. Registration submitted December 6, 2017, first patient enrolled October 2017.
目的
测试针对 NF 患者的身心弹性恢复计划——多发性神经纤维瘤（3RP-NF）对弹性因素的影响，该计划是一项针对 NF 患者的身心弹性恢复计划，旨在从基线到治疗后以及 6 个月和 12 个月的随访期间测试弹性因素。
方法
这是对 3RP-NF 和健康教育对照（HEP-NF）的完全有力的随机临床试验（RCT）的二次分析。我们招募了报告压力或难以应对 NF 症状的 NF1、NF2 或 schwannomatosis 成人。两种情况均接受 8 周每周 90 分钟的小组会议；3RP-NF 专注于建立弹性技能。我们通过当前状态量表 A（适应性应对）、认知和情感正念量表修订版（正念）、感恩问卷 6（感恩）、生活取向测试乐观量表（乐观）和医疗结果研究社会支持调查（感知社会支持）在基线、干预后以及 6 个月和 12 个月的随访中测量弹性因素。我们使用具有完全非结构化协方差的线性混合模型，最多可对四个重复测量（基线、治疗后以及 6 个月和 12 个月的随访）进行分析，以研究治疗对弹性因素的影响。
结果
我们招募了 228 名个体（M=42.7，SD=14.6；74.5%女性；87.7%白人；72.8% NF1，14.0% NF2，13.2% schwannomatosis）。在组内，3RP-NF 和 HEP-NF 均在所有时间点的所有结果上均显示出统计学上的显著改善。与 HEP-NF 相比，3RP-NF 从基线到干预后以及从基线到 6 个月的适应性应对能力有显著改善（M=0.29；95%CI 0.13-0.46；p<0.001；M=0.25；95%CI 0.07-0.33；p=0.005）；在其余的弹性因素中，两组之间没有其他差异。
结论
3RP-NF 显示出在可持续改善 NF 患者应对能力方面的前景。
试验注册信息
ClinicalTrials.gov 标识符：NCT03406208。注册提交于 2017 年 12 月 6 日，首位患者于 2017 年 10 月入组。
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