Integrated Brain Health Clinical and Research Program, Psychiatry Department, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA.
Harvard Medical School, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA.
J Neurooncol. 2020 Apr;147(2):451-457. doi: 10.1007/s11060-020-03441-8. Epub 2020 Feb 20.
To examine effects of a virtual mind-body group for adolescents with neurofibromatoses (NF1 and NF2; Resilient Youth with Neurofibromatosis; RY-NF) on multiple resiliency factors against a health education attention control (Health Education for Youth with Neurofibromatosis; HE-NF) using data from a randomized controlled trial. Specifically, our research question was whether adolescents randomized to the RY-NF (versus the HE-NF) would have greater improvements in resiliency factors at post-intervention and whether these gains would be maintained at 6-month follow-up.
Adolescents with NF (n = 51; M age 12-17) were randomly assigned to RY-NF (n = 27) or HE-NF (n = 24). Resiliency factors (mindfulness, coping, gratitude, optimism, and social support) were collected at baseline, post-intervention (88%), and 6-month follow-up (82%).
Participation in the RY-NF was associated with greater pre-to-post improvements in gratitude (M = 4.38; 95% CI-0.52-8.23; p = .027) and mindfulness (M= 9.41; 95% CI 4.40-14.42.; p < .001) compared to HE-NF; improvements sustained at 6 months. There were no group differences on any additional resiliency factors. However, participation in the RY-NF was associated with pre-to-post- improvements in coping (M= 9.16; 95% CI 2.93-15.39; p = .005), and social support (M= 6.79; 95% CI 1.96-11.63; p = .007); improvements sustained at 6 months.
Participation in the RY-NF resulted in sustained improvement in several resiliency factors. Promoting resiliency may help adolescents successfully navigate challenges associated with NF.
通过一项随机对照试验的数据，检验针对神经纤维瘤病青少年（NF1 和 NF2；神经纤维瘤病青少年的韧性；RY-NF）的虚拟身心团体治疗对多种韧性因素的影响，与健康教育对照（神经纤维瘤病青少年健康教育；HE-NF）。具体来说，我们的研究问题是，与 HE-NF 相比，接受 RY-NF 治疗的青少年在干预后是否会在韧性因素上有更大的改善，以及这些改善是否能在 6 个月的随访中得到维持。
将 51 名 NF 青少年（M 年龄 12-17）随机分配到 RY-NF（n=27）或 HE-NF（n=24）。在基线、干预后（88%）和 6 个月随访（82%）时收集韧性因素（正念、应对、感恩、乐观和社会支持）。
与 HE-NF 相比，RY-NF 的参与与感恩（M=4.38；95%CI-0.52-8.23；p=0.027）和正念（M=9.41；95%CI 4.40-14.42；p<0.001）的改善更显著；这些改善在 6 个月时仍能维持。在其他韧性因素上，两组之间没有差异。然而，RY-NF 的参与与应对（M=9.16；95%CI 2.93-15.39；p=0.005）和社会支持（M=6.79；95%CI 1.96-11.63；p=0.007）的改善有关；这些改善在 6 个月时仍能维持。
RY-NF 的参与导致了几个韧性因素的持续改善。促进韧性可能有助于青少年成功应对神经纤维瘤病相关的挑战。
