Guckel Tara, Prior Katrina, Newton Nicola Clare, Stapinski Lexine Ann
The Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia.
JMIR Res Protoc. 2023 Jul 13;12:e48875. doi: 10.2196/48875.
Anxiety and alcohol use commonly co-occur. Previous research has demonstrated the bidirectional and mutually reinforcing nature of this relationship, with an increasing body of research investigating the mediating and moderating mechanisms driving this association. Within the existing mediation and moderation research, however, there have been contrasting findings and, at times, null results among some population groups.
This protocol outlines a systematic review and meta-analysis aiming to synthesize and clarify mediators and moderators in the anxiety-alcohol and alcohol-anxiety relationships.
Systematic searches will be conducted in the electronic databases Medline, PsycINFO, Embase, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science to identify studies that investigated mediators and moderators of the relationship between anxiety and alcohol use, including clinical and subclinical levels. Studies that look at the relationship between anxiety and alcohol use outcomes, as well as alcohol use and anxiety outcomes, will be included in order to capture an in-depth understanding of the mechanisms driving the association in either direction. No limits will be placed on study year or study language. Included study designs will be observational studies, including cohort, cross-sectional, and longitudinal studies, and secondary analyses of randomized controlled trials reporting quantitative results. Selected studies will also have their reference lists hand-searched for other relevant papers. Study quality will be assessed with the Joanna Briggs Institute Checklists for Analytical Cross-Sectional Studies and Cohort Studies. Mediators and moderators will be narratively synthesized in line with the biopsychosocial framework, where results will be grouped into biological, psychological, and social or environmental factors. If the data are sufficiently homogeneous, a meta-analysis will be conducted with mediation and moderation analyses synthesized separately. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework will also be used to assess the strength of cumulative evidence.
Electronic database searches were conducted in September 2022. After duplicates were removed, a total of 7330 titles and abstracts were screened. Full-text reviewing is currently under way, with the results expected to be available by the end of 2023.
Given the significant individual and societal impacts of co-occurring anxiety and alcohol use, this review will help clarify mechanisms linking these two concerns. Identified mechanisms, where possible, can then be targeted in prevention, early intervention, and treatment approaches to improve the outcomes for individuals experiencing co-occurring anxiety and alcohol use.
PROSPERO CRD42023358402; https://tinyurl.com/2m2e3enp.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/48875.
焦虑与酒精使用常常同时出现。先前的研究已经证明了这种关系的双向性和相互强化性，越来越多的研究开始探究驱动这种关联的中介和调节机制。然而，在现有的中介和调节研究中，不同人群组的研究结果存在差异，有时甚至得出无显著结果。
本方案概述了一项系统评价和荟萃分析，旨在综合并阐明焦虑与酒精使用关系以及酒精使用与焦虑关系中的中介因素和调节因素。
将在电子数据库Medline、PsycINFO、Embase、Cochrane对照试验中心注册库、Scopus和Web of Science中进行系统检索，以识别研究焦虑与酒精使用关系的中介因素和调节因素的研究，包括临床和亚临床水平。研究焦虑与酒精使用结果之间的关系以及酒精使用与焦虑结果之间关系的研究将被纳入，以便深入了解驱动双向关联的机制。对研究年份或研究语言不设限制。纳入的研究设计将包括观察性研究，如队列研究、横断面研究和纵向研究，以及报告定量结果的随机对照试验的二次分析。还将人工检索所选研究的参考文献列表以查找其他相关论文。将使用乔安娜·布里格斯研究所分析性横断面研究和队列研究清单评估研究质量。中介因素和调节因素将根据生物心理社会框架进行叙述性综合，结果将分为生物、心理和社会或环境因素。如果数据足够同质，将分别进行中介分析和调节分析的荟萃分析。还将使用推荐分级、评估、制定和评价（GRADE）框架评估累积证据的强度。
2022年9月进行了电子数据库检索。去除重复项后，共筛选了7330篇标题和摘要。目前正在进行全文评审，预计结果将于2023年底公布。
鉴于焦虑与酒精使用同时出现对个人和社会有重大影响，本综述将有助于阐明连接这两个问题的机制。在可能的情况下，确定的机制可作为预防、早期干预和治疗方法的目标，以改善同时患有焦虑和酒精使用问题的个体的治疗效果。
PROSPERO CRD42023358402；https://tinyurl.com/2m2e3enp。
国际注册报告识别号（IRRID）：DERR1-10.2196/48875。
