水中铜催化胺与芳基碘鎓叶立德的芳基化反应。
Copper-catalyzed -arylation of amines with aryliodonium ylides in water.
作者信息
Nabar Kasturi U, Bhanage Bhalchandra M, Dawande Sudam G
机构信息
Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga East, Mumbai-400019, Maharashtra, India.
Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036, Tamilnadu, India.
出版信息
Beilstein J Org Chem. 2023 Jul 4;19:1008-1014. doi: 10.3762/bjoc.19.76. eCollection 2023.
Copper sulfate catalyzed an efficient, inexpensive, and environment-friendly protocol that has been developed for -arylation of amines with 1,3-cyclohexadione-derived aryliodonium ylides in water as a green solvent. Aromatic primary amines substituted with electron-donating as well as electron-withdrawing groups on the aryl ring reacted smoothly with iodonium ylides to give the corresponding diarylamines with good to excellent yields. Also, secondary amines underwent -arylation to deliver tertiary amines with moderate yields.
硫酸铜催化了一种高效、廉价且环境友好的方法，该方法已被开发用于在水作为绿色溶剂的条件下，使胺与1,3 -环己二酮衍生的芳基碘鎓叶立德进行芳基化反应。芳环上带有供电子基团以及吸电子基团的芳香伯胺与碘鎓叶立德顺利反应，以良好至优异的产率得到相应的二芳基胺。此外，仲胺进行芳基化反应，以中等产率得到叔胺。
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