Doar Nyier W, Samuthiram Shamini D
Medicine, Interfaith Medical Center, New York, USA.
Medicine, Medical University of the Americas, Charlestown, KNA.
Cureus. 2023 Jun 11;15(6):e40261. doi: 10.7759/cureus.40261. eCollection 2023 Jun.
Antibiotic-associated diarrhea is often managed by the withdrawal of the culprit antibiotics or the administration of alternative antibiotics when a infection (CDI) is suspected, an infection that tends to be the most common causative agent of the disease. Probiotics are also gaining popularity as alternative therapies, and it was hypothesized in this article that a Lactobacillus strain is the most efficacious probiotic for the prevention of antibiotic-associated diarrhea. This article conducted a literature review investigating the relative efficacy of the Lactobacillus, Bifidobacterium, and Saccharomyces probiotic strains as effective alternative therapies for antibiotic-associated diarrhea. The literature searched was from the PubMed database. The inclusion filters were: random control trials (RCTs), clinical trials, meta-analysis, last 10 years, full-text articles available in English, and all articles published in peer-reviewed journals. All three probiotic genera had strains that demonstrated significant efficacy in the prevention of antibiotic-associated diarrhea. However, I-745 tends to outperform all the strains as the most effective and the one with the fewest, if any, adverse effects. Whenever probiotics are considered for the prevention of antibiotic-associated diarrhea (AAD) in both pediatric and adult patients, I-745 should probably be prioritized.
抗生素相关性腹泻通常通过停用可疑抗生素来处理，或者在怀疑艰难梭菌感染（CDI）时使用替代抗生素，艰难梭菌感染往往是该病最常见的病原体。益生菌作为替代疗法也越来越受欢迎，本文假设一种乳酸杆菌菌株是预防抗生素相关性腹泻最有效的益生菌。本文进行了一项文献综述，调查乳酸杆菌、双歧杆菌和酿酒酵母益生菌菌株作为抗生素相关性腹泻有效替代疗法的相对疗效。检索的文献来自PubMed数据库。纳入筛选标准为：随机对照试验（RCT）、临床试验、荟萃分析、过去10年、可获取英文全文的文章以及发表在同行评审期刊上的所有文章。所有这三种益生菌属都有在预防抗生素相关性腹泻方面显示出显著疗效的菌株。然而，I-745往往表现优于所有菌株，是最有效的且副作用最少（如果有副作用的话）的菌株。无论何时考虑使用益生菌来预防儿科和成年患者的抗生素相关性腹泻（AAD），I-745可能都应被优先选用。
