基于CD8 T细胞的HIV治愈免疫疗法的最新进展。
Recent advances in CD8 T cell-based immune therapies for HIV cure.
作者信息
Arenas Valentina Restrepo, Rugeles María T, Perdomo-Celis Federico, Taborda Natalia
机构信息
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.
Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia.
出版信息
Heliyon. 2023 Jun 20;9(6):e17481. doi: 10.1016/j.heliyon.2023.e17481. eCollection 2023 Jun.
Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8 T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8 T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies.
实现治愈人类免疫缺陷病毒（HIV）感染是一项全球优先事项。有大量证据支持CD8 T细胞在HIV自然控制中发挥核心作用，这表明可以利用这些细胞来实现该感染的缓解或治愈。在这项工作中，我们回顾了实现HIV治愈所面临的主要挑战、HIV缓解模型以及CD8 T细胞介导的HIV控制机制。此外，我们讨论了基于这一细胞群体可用于寻找HIV治愈方法的策略。最后，我们分析了将这些基础知识转化为可扩展的HIV治愈策略目前所面临的挑战和前景。
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