University of Health Sciences Turkey, Izmir Faculty of Medicine, Dr. Behçet Uz Children's Education and Research Hospital, Department of Pediatrics, Division of Pediatric Neurology, Izmir, Turkey.
University of Health Sciences Turkey, Izmir Faculty of Medicine, Dr. Behçet Uz Children's Education and Research Hospital, Department of Pediatrics, Division of Pediatric Neurology, Izmir, Turkey.
Seizure. 2023 Aug;110:244-252. doi: 10.1016/j.seizure.2023.06.023. Epub 2023 Jun 30.
To compare electroencephalography (EEG) features of newly diagnosed drug-naive childhood absence epilepsy (CAE) and juvenile absence epilepsy (JAE) patients and analyze their response to anti-seizure medications (ASMs).
EEG characteristics between CAE and JAE patients and responders and non-responders to ASM at baseline and 12 months were compared, and the changes from baseline were analysed.
A total of 62 patients (32 CAE and 30 JAE) were included. Discharges in baseline awake and sleep EEGs and interictal and polyspike discharges in baseline sleep EEGs were more frequent in JAE patients. Although the median discharge densities (discharge containing seconds per minute) were similar in baseline awake and sleep EEGs between the groups, the median was higher in the JAE group at 12 months and decreased significantly in both groups at 12 months compared to the baseline values. Responses to initial ASMs were 94% and 77% in the CAE and JAE groups, respectively. In initial sleep EEGs of non-responders with JAE, focal onset generalized spike and slow wave discharges (GSWDs) were more frequent, and the median ictal and interictal discharge densities were higher.
JAE patients had more frequent disorganized discharges at baseline in both awake and sleep EEGs and interictal and polyspike discharges in sleep EEGs than those of CAE patients. Improvement in EEG was more pronounced in CAE patients than in JAE patients. Focal-onset GSWDs and higher ictal and interictal discharge densities on baseline EEG were associated with a poor response to initial ASMs in JAE patients.
比较新诊断的药物初治儿童失神癫痫（CAE）和青少年失神癫痫（JAE）患者的脑电图（EEG）特征，并分析其对抗癫痫药物（ASM）的反应。
比较 CAE 和 JAE 患者以及 ASM 基线和 12 个月时的脑电图特征，分析从基线开始的变化。
共纳入 62 例患者（32 例 CAE 和 30 例 JAE）。JAE 患者的基线清醒和睡眠 EEG 中的放电以及基线睡眠 EEG 中的发作性和多棘波放电更为频繁。尽管两组在基线清醒和睡眠 EEG 中的放电密度（每分钟放电秒数）中位数相似，但 JAE 组在 12 个月时的中位数较高，两组在 12 个月时与基线值相比均显著下降。CAE 和 JAE 组初始 ASM 的反应率分别为 94%和 77%。在 JAE 组的无反应者的初始睡眠 EEG 中，局灶性起始全面性棘慢波放电（GSWD）更为频繁，且发作期和发作间期放电密度中位数较高。
与 CAE 患者相比，JAE 患者在基线时的清醒和睡眠 EEG 中以及睡眠 EEG 中的不规则放电更为频繁，且发作间期和多棘波放电更为频繁。与 JAE 患者相比，CAE 患者的脑电图改善更为明显。基线 EEG 上的局灶性起始 GSWD 和更高的发作期和发作间期放电密度与 JAE 患者对初始 ASM 的反应不良有关。
