Institute of Environmental Science, Shanxi University, Taiyuan 030006, China.
Department of Environmental Health, School of Public Health, Fudan University, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Shanghai 200032, China.
Sci Total Environ. 2023 Nov 1;897:165501. doi: 10.1016/j.scitotenv.2023.165501. Epub 2023 Jul 11.
Numerous epidemiological studies have demonstrated links between short-term ozone exposure to various adverse health outcomes, but some ozone-induced pathological mechanisms remain unclear. To fill this knowledge gap, we enrolled 36 healthy young adults living in high-ozone areas and performed an untargeted metabolomic analysis in serum collected before, during, and after their travel to a low-ozone scenic area. Reviewing the literature, we found 16 metabolites significantly associated with ozone, pointing to neurological health, type 2 diabetes (T2D) risk, and cardiovascular health. Notably, we observed significant changes in these 16 metabolites from the ozone reduction when participants traveled from the campus to the scenic area (adjusted p-value < 0.05). However, when ozone increased after participants returned to campus from the scenic area, we observed that T2D risk and cardiovascular health-related metabolites returned to their original state (adjusted p-value < 0.05), but neurological health-related metabolites did not change significantly with ozone exposure. Our study showed that ozone exposure was linked to prompt alterations in serum metabolites related to cardiovascular health and T2D risk but less sensitive changes in neurological health-related metabolites. Among many lipids, free fatty acids and acylcarnitines were the most sensitive compounds positively associated with changes in ozone exposure.
许多流行病学研究表明，短期臭氧暴露与各种不良健康后果之间存在关联，但一些臭氧诱导的病理机制仍不清楚。为了填补这一知识空白，我们招募了 36 名居住在高臭氧地区的健康年轻成年人，并在他们前往低臭氧风景区前后采集血清进行非靶向代谢组学分析。在回顾文献时，我们发现了 16 种与臭氧显著相关的代谢物，这些代谢物与神经健康、2 型糖尿病（T2D）风险和心血管健康有关。值得注意的是，当参与者从校园前往风景区时，我们观察到这些 16 种代谢物的浓度随着臭氧的减少而显著变化（调整后的 p 值<0.05）。然而，当参与者从风景区返回校园后臭氧增加时，我们发现与 T2D 风险和心血管健康相关的代谢物恢复到原来的状态（调整后的 p 值<0.05），但与神经健康相关的代谢物与臭氧暴露没有显著变化。我们的研究表明，臭氧暴露与心血管健康和 T2D 风险相关的血清代谢物的迅速变化有关，但与神经健康相关的代谢物的变化敏感性较低。在许多脂质中，游离脂肪酸和酰基肉碱是与臭氧暴露变化最相关的最敏感化合物。
