微波辅助合成罗丹明、罗丹醇和荧光素衍生物。
Microwave-Assisted Syntheses of Rhodamine, Rhodol, and Fluorescein Derivatives.
作者信息
Chieffo Carolina, Altamura Emiliano, Pilet Guillaume, Mebarek Saida, Strazewski Peter, Fiore Michele
机构信息
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS, UMR 5246), Université Claude Bernard Lyon 1, 1 Rue Victor Grignard, 69100, Villeurbanne, France.
Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France.
出版信息
Chempluschem. 2023 Jul;88(7):e202300189. doi: 10.1002/cplu.202300189.
A series of rhodol-; fluorescein- and rhodamines-based spirolactam compounds, bearing electron donor amines have been prepared. For this purpose we have redesigned the synthesis of the rhodol scaffold using 2-(2,4-dihydroxybenzoyl)benzoic acid obtaining one example rhodol methyl ester in good yields (25-30 %) Thus, one set of non-cytotoxic rhodamine-based compounds has been prepared using thermal and microwave assisted synthesis (40-78 %) and tested as high affinity ATP chemo-sensors.
我们设计了一种新的方法，通过使用 2-(2,4-二羟基苯甲酰基)苯甲酸来合成 rhodol 骨架，得到了一个 rhodol 甲酯的实例，收率为 25-30%。因此，我们使用热法和微波辅助法（40-78%）合成了一组非细胞毒性的基于罗丹明的化合物，并将其作为高亲和力的 ATP 化学传感器进行了测试。
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