Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Oakland Veterinary Referral Services, Bloomfield Township, Michigan, USA.
Vet Ophthalmol. 2024 Mar;27(2):158-169. doi: 10.1111/vop.13132. Epub 2023 Jul 13.
To document ocular lesions and establish ophthalmic diagnostic test reference values in a colony of African green monkeys (Chlorocebus aethiops sabaeus).
Fifty one geriatric (GAGM, 19-30 years old), 10 adult (AAGM, 5-9 years old) and 10 juvenile (JAGM, <2 years old) African green monkeys housed in a single Caribbean research colony.
Ocular biomicroscopy, indirect fundoscopy, Schirmer tear test (STT), rebound tonometry (TonoVet®) and corneal fluorescein staining were performed. Mixed ANCOVA tests were performed to compare STT and IOP between groups.
Common ocular lesions in GAGM included vitreal degeneration (27/51, 51/102 eyes) and cataracts (21/51, 32/102 eyes). Vitreal degeneration was also common in AAGM (8/10, 16/20 eyes) and infrequent in JAGM (3/10, 6/20 eyes). Cataracts were not present in any JAGM or AAGM. All eyes in all three groups had perilimbal corneal pigmentation and faint lace-like anterior corneal stromal opacification. Median (range) STT values were 16.0 (18) mm/min in GAGM. Mean (SD) STT values were 14.2 (4.6) mm/min in AAGM, and 8.9 (3.4) mm/min in JAGM. Median (range) IOP values were 16.5 (27) mmHg in GAGM. Mean (SD) IOP values were 18.0 (2.8) mmHg in AAGM, and 14.1 (2.2) mmHg in JAGM. JAGM had significantly lower STT and IOP values compared to AAGM (p = .0449, .0057, respectively) and GAGM (p = .0002, .0130, respectively).
Spontaneous ocular lesions were common in geriatric monkeys in this research colony. IOP and STT values were lower in juvenile African green monkeys relative to adult or geriatric animals.
记录非洲绿猴（Chlorocebus aethiops sabaeus）群体中的眼部病变，并建立眼科诊断测试参考值。
51 只老年（GAGM，19-30 岁）、10 只成年（AAGM，5-9 岁）和 10 只幼年（JAGM，<2 岁）非洲绿猴饲养在一个加勒比研究群体中。
进行眼部生物显微镜检查、间接眼底镜检查、泪液分泌试验（STT）、回弹眼压计（TonoVet®）和角膜荧光素染色。采用混合方差分析（ANCOVA）比较各组之间的 STT 和眼压。
GAGM 中常见的眼部病变包括玻璃体变性（27/51，51/102 眼）和白内障（21/51，32/102 眼）。玻璃体变性在 AAGM 中也很常见（8/10，16/20 眼），在 JAGM 中很少见（3/10，6/20 眼）。JAGM 或 AAGM 中均未见白内障。三组所有眼睛均有边缘角膜色素沉着和微弱的蕾丝状前角膜基质混浊。GAGM 中 STT 值的中位数（范围）为 16.0（18）mm/min。AAGM 中平均（SD）STT 值为 14.2（4.6）mm/min，JAGM 中为 8.9（3.4）mm/min。GAGM 中 IOP 值的中位数（范围）为 16.5（27）mmHg。AAGM 中平均（SD）IOP 值为 18.0（2.8）mmHg，JAGM 中为 14.1（2.2）mmHg。JAGM 的 STT 和眼压值明显低于 AAGM（p=0.0449，0.0057）和 GAGM（p=0.0002，0.0130）。
在这个研究群体中，老年猴子中自发性眼部病变很常见。与成年或老年动物相比，幼年非洲绿猴的眼压和 STT 值较低。
