骶神经调节治疗大便失禁患者:长期疗效及对性功能的影响。

Sacral nerve modulation for patients with fecal incontinence: long-term outcome and effects on sexual function.

机构信息

Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

III Department of Surgery, "A. Cardarelli" Hospital, Naples, Italy.

出版信息

Updates Surg. 2023 Aug;75(5):1187-1195. doi: 10.1007/s13304-023-01570-z. Epub 2023 Jul 13.

Abstract

Sacral nerve modulation has become an established treatment for fecal and urinary incontinence, and sexual disorders. The objective of this study was to evaluate the long-term outcome of sacral neuromodulation in patients with fecal or combined fecal and urinary incontinence (double incontinence), assessing its safety, efficacy, and impact on quality of life and sexual function. This was a multicentric, retrospective, cohort study including patients with fecal or double incontinence who received sacral neuromodulation at seven European centers between 2007 and 2017 and completed a 5-year follow-up. The main outcome measures included improvements of incontinence symptoms and quality of life compared with baseline, evaluated using validated tools and questionnaires at 1-, 6-, 12-, 36- and 60-month follow-up. 108 (102 women, mean age 62.4 ± 13.4 years) patients were recruited, of whom 88 (81.4%) underwent definitive implantation of the pacemaker. Patients' baseline median Cleveland Clinic Incontinence Score was 15 (10-18); it decreased to 2 (1-4) and 1 (1-2) at the 12- and 36-month follow-up (p < 0.0001), remaining stable at the 5-year follow-up. Fecal incontinence quality of life score improved significantly. All patients with sexual dysfunction (n = 48) at baseline reported symptom resolution at the 5-year follow-up. The study was limited by the retrospective design and the relatively small patient sample. Sacral nerve modulation is an effective treatment for fecal and double incontinence, achieving satisfactory long-term success rates, with resolution of concomitant sexual dysfunction.

摘要

骶神经调节已成为治疗粪便和尿失禁以及性功能障碍的既定方法。本研究的目的是评估骶神经调节对粪便或粪便和尿混合失禁(双重失禁)患者的长期疗效,评估其安全性、疗效以及对生活质量和性功能的影响。这是一项多中心、回顾性队列研究,纳入了 2007 年至 2017 年期间在欧洲 7 个中心接受骶神经调节治疗并完成 5 年随访的粪便或双重失禁患者。主要观察指标包括使用经过验证的工具和问卷在 1、6、12、36 和 60 个月随访时评估与基线相比失禁症状和生活质量的改善。共纳入 108 例(102 例女性,平均年龄 62.4±13.4 岁)患者,其中 88 例(81.4%)接受了起搏器的最终植入。患者的基线克利夫兰诊所失禁评分中位数为 15(10-18);在 12 个月和 36 个月随访时分别降至 2(1-4)和 1(1-2)(p<0.0001),在 5 年随访时保持稳定。粪便失禁生活质量评分显著改善。所有基线时有性功能障碍的患者(n=48)在 5 年随访时均报告症状缓解。本研究的局限性在于回顾性设计和相对较小的患者样本。骶神经调节是治疗粪便和双重失禁的有效方法,可获得令人满意的长期成功率,并解决伴随的性功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba0/10359216/dd316d0469cc/13304_2023_1570_Fig1_HTML.jpg

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