Garg Ishu, Verma Madhu, Kumar Harish, Maurya Ravi, Negi Tushar, Jain Prityush
Sardar Bhagwan Singh University, Dehradun, Uttarakhand, India.
ITS College of Pharmacy, Ghaziabad, Uttar Pradesh, India.
Bioelectricity. 2025 Mar 18;7(1):2-28. doi: 10.1089/bioe.2024.0039. eCollection 2025 Mar.
The emerging field of bioelectronic therapeutics unfolds great opportunities for treating numerous neurological and inflammatory conditions by utilizing the amalgamation of molecular medicine, neuroscience, engineering, and computing. These innovative treatments leverage advanced technology to precisely identify, design, and regulate electrical signaling patterns in the nervous system, addressing multiple diseases. Modifying neural signaling patterns to produce therapeutic effects at a particular organ may blur the lines between conventional medical practices. These modify the neurological behavior using electrical, magnetic, optical, and ultrasonic pulses through closed-loop systems to optimize neural behavior. The Food and Drug Administration (FDA) has approved numerous invasive and noninvasive bioelectronic devices, in the treatment of various neuronal diseases and non-neuronal diseases. Furthermore, the FDA has approved many devices for clinical studies. The field of bioelectronics encounters challenges in integrating with the health care system, including incomplete understanding of human nervous anatomy, neuronal function, membrane potential, and technological limitations. This review aims to explore bioelectronics therapeutics, their role or action in challenges to growth and their solutions, and the prospects of bioelectronic therapeutics.
生物电子治疗这一新兴领域通过融合分子医学、神经科学、工程学和计算机科学,为治疗多种神经和炎症性疾病带来了巨大机遇。这些创新疗法利用先进技术精确识别、设计和调节神经系统中的电信号模式,从而应对多种疾病。通过闭环系统利用电、磁、光和超声波脉冲改变神经信号模式以在特定器官产生治疗效果,这可能会模糊传统医疗实践之间的界限。这些通过闭环系统利用电、磁、光和超声波脉冲来改变神经行为,以优化神经功能。美国食品药品监督管理局(FDA)已批准了众多侵入性和非侵入性生物电子设备用于治疗各种神经元疾病和非神经元疾病。此外,FDA还批准了许多用于临床研究的设备。生物电子学领域在与医疗保健系统整合方面面临挑战,包括对人体神经解剖结构、神经元功能、膜电位的不完全理解以及技术限制。本综述旨在探讨生物电子治疗、它们在成长挑战中的作用或作用方式及其解决方案,以及生物电子治疗的前景。